Medical Pharmacology Chapter 33-34: Cancer Chemotherapy L-Asparaginase

Concerning L-asparaginase:
1. L-asparaginase is a standard drug for treating acute lymphoblastic leukemia.
2. Malignant lymphoid cells typically synthesize the important amino acid L-asparagine.
3. Both
4. Neither
L-asparaginase is often administered in combination with which one(s) of the following In the context of treating high-grade lymphomas and acute lymphoblastic leukemia?
1. Methotrexate
2. Doxorubicin
3. Prednisone
4. A & B
5. B & C
6. A, B & C
Resistance to anticancer effects of L-asparaginase may occur through tumor cell synthesis of asparagine synthase.
1. True
2. False
Toxicity/toxicities associated with L-asparaginase administration is/are a result of which one(s) of the following?
1. Protein synthesis inhibition
2. Antigenic effects, since L-asparaginase is recognized by the immune system as a foreign protein.
3. Both
4. Neither
Adverse effects/effects associated with L-asparaginase administration:
1. Blood clotting abnormalities, such as spontaneous thrombosis.
2. Pancreatitis
3. Both
4. Neither
Concerning L-asparaginase pharmacokinetics:
1. Drug plasma half-life is about 30 hours.
2. Drug blood levels appear to be proportional to dosage.
3. Both
4. Neither
Hypersensitivity reactions to L-asparaginase administration includes/include:
1. Laryngospasm
2. Urticaria
3. Both
4. Neither
Cautious use of L-asparaginase is appropriate in which one(s) of the following?
1. Pancreatitis
2. Hepatic dysfunction
3. Both
4. Neither
L-asparaginase associated antitumor action occurs because of a near-complete and rapid depletion of circulating L-asparagine.
1. True
2. False
L-asparaginase may be administered by which one(s) of the following routes of administration?
1. Intramuscular (IM)
2. Intravenous (IV)
3. Both
4. Neither