Medical
Pharmacology Practice Questions: Cancer Chemotherapy Mitotane
Click on the correct answer.
Mitotane:
Chemically similar to the insecticide DDT.
May be used in the treatment of adrenal cortex carcinoma.
Both
Neither
Adrenocortical carcinoma (adrenal cortex carcinoma): If clinical assessment suggests adrenocortical carcinoma (ACC), open approach surgery represents the treatment of choice.
True
False
Pharmacological action/actions of mitotane:
Directly suppresses the adrenal cortex
Alters steroid peripheral metabolism
Both
Neither
Mitotane is considered an adrenolytic agent
True
Volves
Mitotane pharmacodynamics, pharmacokinetics: choose the correct statements/statements:
Mitotane following oral administration exhibits and absorption of about 40%.
The primary site of mitotane systemic storage Is in the fat.
Both
Neither
Mitotane metabolism and elimination:
Mitotane metabolism is mainly hepatic, resulting in a water-soluble metabolite found in the urine (about 25% of an oral or parenteral dose)
Half-life of elimination is about 50 days (median).
Both
Neither
Mitotane induces the liver microsomal drug metabolism isoform CYP3A4 and therefore may cause drug-drug interactions.
True
False
Concerning mitotane therapeutics:
Treatment should usually continue for about three months.therapy following observation of clinical benefit may require indefinite maintenance administration.
Spirolactone should be administered along with mitotane to enhance adrenal suppression.
Both
Neither
Mitotane may be useful in palliation of inoperable adrenocortical carcinoma (symptomatic benefit in about 40% of patients).
True
False
Mitotane adverse effect/effects.
Mitotane administration results in him adrenocortical damage requiring adrenocortical steroid replacement treatment.
Anorexia and nausea is often observed following mitotane administration.
