Medical Pharmacology: Antifungal Drug Practice Questions

**Dimorphic Fungi**

Griseofulvin is not effective against yeast (and yeast-like) dimorphic fungi. Dimorphic fungi exists as both yeast and filamentous cells (other forms are also likely for dimorphic fungi). Attribution: Garnhami, CC BY-SA 4.0 <https://creativecommons.org/licenses/by-sa/4.0>, via Wikimedia Commons https://commons.wikimedia.org/wiki/File:Candida_albicans_growing_as_yeast_cells_and_filamentous_(hypha)_cells.jpg

Dimorphic Fungi

Griseofulvin is not effective against yeast (and yeast-like) dimorphic fungi. Dimorphic fungi exists as both yeast and filamentous cells (other forms are also likely for dimorphic fungi).
Attribution:
- Garnhami, CC BY-SA 4.0 <https://creativecommons.org/licenses/by-sa/4.0>, via Wikimedia Commons
- https://commons.wikimedia.org/wiki/File:Candida_albicans_growing_as_yeast_cells_and_filamentous_(hypha)_cells.jpg

Source Material:
- Rogers PD Krysan DJ Chapter 61 Antifungal Agents. In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw HIil LLC (2023).
- Griffith RK Ch 31 Drugs Used to Treat Fungal Infections in Foye's Principles of Medicinal Chemistry 8e (Roche VG Zite SW Lemke TL Williams DA, eds) Wolters-Kluwer 2020.
- Canonica T Mulliken JS Lampiris HW Maddix DS Antifungal Agents Ch 48 in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.
- Lionakis MS Edwards Jr JE Ch 211 Pathogenesis, Diagnosis, and Treatment of Fungal Infections in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Hage CA Histoplasmosis Ch 212 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Ampel NM Coccidioidomycosis CH 213 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Gauthier GM Klein BS Blastomycosis CH 214 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Casadevall A Cryptococcosis CH 215 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Lionakis MS Singh S Ibrahim AS Edwards JR JE Candidiasis CH 216 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Spellberg B Ibrahim Mucormycosis AS CH 218 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Morris A Masur H Pneumocystis CH 220 in Harrison's Principles of Internal Medicine, 21e, McGraw-Hill 2022.
- Ma C Armstrong AW Pharmacology of Fungal Infections CH 36 in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017.
- Griseofulvin: https://en.wikipedia.org/wiki/Griseofulvin
- Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Chapter 54 Antifungal drugs Rang & Dale's Pharmacology 10e Elsevier 2024.
- Stevens DA Denning DW Ch 315: Systemic Antifungal Agents in in Goldman-Cecil Medicine E-Book (Goldman L Schafer AI, eds) 26e Elsevier 2020.