Medical Pharmacology: Antifungal Drug Practice Questions

Topical Antifungal Agents: Econazole, Efinaconazole (Jublia), Miconazole (Zeasorb)

Econazole (Ecosza):
1. Derivative of miconazole
2. Good concentration in the middermis
3. Both
4. Neither
Econazole (Ecosza) side effects/effects-low incidence (about 3%):
1. Stinging/itching
2. Localized erythema
3. Both
4. Neither
Econazole (cream formulation) may be used for treating tinea pedis, tinea cruris and tinea corporis. These infections may be caused by which one(s) of the following:
1. Microsporum canis
2. Microsporum gypseum
3. Epidermophyton floccosum
4. All of the above
Longest recommended duration of treatment with econazole nitrate cream:
1. Candidal infections
2. Tinea corporis
3. Tinea pedis
Econazole nitrate in pregnancy:
1. First trimester use only of physician considers administration "essential" for patient welfare.
2. Econazole Nitrate used during the second and third trimester only if "clearly needed."
3. Both
4. Neither
Efinaconazole (Jublia):
1. In vitro activity against Trichophyton rubrum and Trichophyton mentagrophytes
2. Treatment: onchomycosis (10% topical)
3. Both
4. Neither
Miconazole (Zeasorb and others):
1. Readily enters skin stratum corneum
2. Persists in the skin for an excess of four days following application.
3. Both
4. Neither
Following vaginal application, miconazole may induce localized burning/itching/irritation in about 7% of patients.
1. True
2. False
Although miconazole is viewed as safe for use during pregnancy, some experts recommend avoiding vaginal use during the first trimester.
1. True
2. False
Miconazole nitrate used for treating vulvovaginal candidiasis is associated with a cure rate (mycological) after one month of administration of about 80%-95%.
1. True
2. False