Antiviral Pharmacology:  Antiviral Drug Videos

Previous Page

Kaposi Sarcoma

Kaposi's Sarcoma: The Disease  (Click to go to Content)

  • Attribution:  Donald Ganem (3/2010)

  • "In 1872, Moritz Kaposi first described a disease that included pigmented skin tumors and in some cases tumors of the viscera.

  • While KS has been endemic in some areas of the world for many years, a highly aggressive and deadly form of the disease emerged concurrently with the HIV/AIDS epidemic.

  • "KS is a very unusual cancer including multiple cell types, including cells of a spindle morphology, in a single tumor. In this section of the talk, the atypical biology of this cancer it will be discussed.

  • "Epidemiological studies suggested that HIV was not the causative agent of KS.

  • "In the mid-1990s, a new human herpes virus, Kaposis sarcoma associated herpes virus (KSHV), was identified as the likely cause of KS.

    • "Development of a serological test for the presence of KSHV in patients showed that KS seroprevalence strikingly mirrored KS risk and, additionally, KS was never found in KSHV negative patients.

  • "This data strongly supported KSHV as the causative agent of KS.

    • However, epidemiology also showed that additional cofactors are required for disease development and in the case of patients with AIDS, HIV is this cofactor

  • Don Ganem left the University of California, San Francisco in 2011 to join the Novartis Institutes for Biomedical Research in Emeryville, CA."

Previous Video

Next Video