Medical Pharmacology: Antiviral Drugs

**"HIV Among Pregnant Women, Infants, and Children"¹⁰**
"Fast Facts" "All pregnant women should be screened for HIV as early as possible during each pregnancy. "Women with HIV who take antiretroviral medication during pregnancy as recommended can reduce the risk of transmitting HIV to their babies to less than 1%. "HIV disproportionately affects black/African American children in the United States
"HIV transmission from mother to child during pregnancy, labor and delivery, or breastfeeding is known as perinatal transmission and is the most common route of HIV infection in children. "When HIV is diagnosed before or during pregnancy, perinatal transmission can be reduced to less than 1% if appropriate medical treatment is given, the virus becomes undetectable, and breastfeeding is avoided. "Since the mid-1990s, HIV testing and preventive interventions have resulted in more than a 90% decline in the number of children perinatally infected with HIV in the United States."

"The Numbers" "In 2010, an estimated 217 children younger than the age of 13 years were diagnosed with HIV in the 46 states with long-term, confidential name-based HIV infection reporting since at least 2007; 162 (75%)1 of those children were perinatally infected. "At the end of 2009, an estimated 10,834 persons who were diagnosed with HIV when they were younger than 13 years were living in the 46 states with long-term, confidential name-based HIV reporting. Of the total, 9,522 (88%) of these persons acquired HIV perinatally. Of these diagnoses of perinatal HIV infection, 63% were in blacks/African Americans, 22% were in Hispanics/Latinos,2 and 13% were in whites. These numbers include persons of all ages who were infected with HIV as children. "The number of women with HIV giving birth in the United States increased approximately 30%, from 6,000–7,000 in 2000 to 8,700 in 2006. "Despite the increase in the number of women with HIV giving birth, the estimated number of perinatal HIV infections per year in all 50 states and 5 US dependent areas continues to decline. "Among perinatally infected children born during 2007 through 2009, black/African American children had the highest HIV rate per 100,000 live births each year, although the rate decreased from 15.2 in 2007 to 9.9 in 2009. The rates for Hispanic/Latino and white children remained stable during this time. "From the beginning of the epidemic through 2009, an estimated 5,626 people who were diagnosed with AIDS when they were younger than 13 years died in the 50 states and the District of Columbia. Of the total, 4,986 (89%) of them were infected perinatally."
"Prevention Challenges" "The reduction in perinatal HIV infections in the United States represents an important achievement in public health. However, perinatal transmission of HIV continues to occur—and infant infections can be associated with interruptions of care at any stage of pregnancy for HIV-infected women and their infants. "The following challenges can be categorized as missed opportunities in preventing perinatal HIV transmission: "Enhanced primary HIV prevention strategies for women and girls continue to be needed and evaluated to prevent new infections in these populations, which will in turn, prevent perinatal HIV infections. "Few HIV medical care providers routinely provide preconception care or family planning services to their patients with HIV, which may result in unintended pregnancies. "Other missed opportunities for perinatal HIV prevention include lack of the following: appropriate prenatal care, prenatal HIV testing (see bullet below), prenatal antiretroviral medication, Cesarean delivery for women with a viral load greater than 1,000 copies/mL, and education on avoidance of breastfeeding. Among the mothers of HIV-infected infants reported to CDC from 2003–2007, only 62% had at least one prenatal visit, 27% were diagnosed with HIV after delivery, and only 29% received some antiretroviral medication during pregnancy. "HIV testing. Because approximately 18% of all people with HIV do not know their HIV status, many women who are infected with HIV may not know they are infected. The Centers for Disease Control and Prevention (CDC) recommends routine, opt-out3 HIV testing for all persons aged 13–64 years in health care settings, including women during every pregnancy. If women are tested and diagnosed with HIV infection before or early in their pregnancy, they can be given medication to improve their own health and reduce the risk of transmitting HIV to their infant. "Other factors also pose prevention challenges, including Substance abuse, mental illness, and HIV-related stigma present barriers to prenatal care in women living with HIV. Increasing accessibility to prenatal care services is crucial to sustain and maximize the decline in perinatal HIV infections. "Socioeconomic issues associated with poverty, including limited access to high-quality health care, housing, and HIV prevention education, may directly or indirectly increase the risk factors for HIV infection. "Lack of awareness that pre-chewing of food for infants is a transmission risk. Of the more than 140,000 HIV-serodiscordant heterosexual couples (one partner is HIV-infected and the other is not) in the United States, about half of them want additional children; and many of these couples have limited access to safe conception methods and services." CDC: Centers for Disease Control and Prevention: HIV Among Pregnant Women, Infants, and Children, reviewed January 10, 2014