Medical Pharmacology Chapter 36:  Antiviral Drugs

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Histoplamosis:  Skin Lesion

  • CDC (Centers for Disease Control)/ Susan Lindsley, VD

  • "This patient presented with a skin lesion on his upper lip.

    • "The ulcer was originally thought to be due to a syphilitic infection, but later, after laboratory testing, was diagnosed as histoplasmosis, due to the fungus Histoplasma capsulatum.

    • "Skin lesions such as this can be a manifestation of “disseminated histoplasmosis”, referring to the spread of the fungal pathogen, H. capsulatum, throughout the body including the skin, bone marrow, brain and other organs.

    • "Disseminated histoplasmosis is most common amongst immunosuppressed people, such as those with AIDS."



Histoplamosis Capsulatum

  • CDC (Centers for Disease Control)/ Dr. Libero Ajello

  • "Note the histopathologic changes seen in histoplasmosis due to Histoplasma capsulatum using methenamine silver stain.

  • "Note the presence of typical yeast cells, some of which are undergoing replication by 'budding'.

  • Histoplasmosis may be confined to the lungs, or become systemically disseminated, thereby, producing a fatal outcome."




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