Medical Pharmacology: Antiviral Drug Practice Questions

Docosanol (Abreva):
1. Fusion inhibitor of the host cell plasma membrane with the herpes simplex viral envelope.
2. When administered at the time of prodromal symptoms (early) and with appropriate application frequency, docosanol shortens healing time in the context of recurring orolabial herpes.
3. Both
4. Neither
Which one(s) of the following statements is/are correct concerning drug prototypes:
1. Herpes simplex virus infection: acyclovir (Sotavog. Zovirax)
2. Cytomegalovirus infections: ganciclovir (Zirgan)
3. Both
4. Neither
Drug most useful in prophylaxis with respect respiratory syncytial viral infections:
1. Oseltamivir (Tamiflu)
2. Palivizumab (Synagis)
3. Simeprevir (Olysio)
4. Baloxavir marboxil (Xofluza)
Drug typically associated with management of hepatitis
1. Ganciclovir
2. Oseltamivir
3. Acyclovir
4. Declatasvir (Daklinza)
Which one/ones the following drugs may be useful in treating hepatitis:
1. Lamivudine (Epivir)
2. Sofosbuvir (Sovaldi)
3. Peginterferon alfa-2a (Pegasys and others)
4. A & B
5. B & C
6. A & C
7. A, B & C
Least sensitive to the action of acyclovir:
1. Herpes simplex virus (HSV)
2. Varicella zoster virus (VSV)
3. Human cytomegalovirus (HCMV)
HCMV exhibits reduced sensitivity to acyclovir compared to HSV or VZV since less active phosphorylated-acyclovir concentrates in HCMV-infected cells compared to HSV or VSV-infected cells. [Attribution: Principles of Pharmacology: the Pathophysiologic Pasis of Drug Therapy]
1. True
2. False
Ganciclovir exhibits enhanced potency compared to acyclovir against human cytomegalovirus.
1. True
2. False
Ganciclovir:
1. Resembes the natural chemical deoxyguanosine.
2. The similar structure of ganciclovir and deoxyguanosine may be responsible for the drugs toxicity.
3. Both
4. Neither
Ganciclovir, by contrast acyclovir and HSV, is selective against human cytomegalovirus only at the phosphorylation step.
1. True
2. False