Medical Pharmacology: Antiviral Drug Practice Questions

Medical Pharmacology: Antiviral Drug Practice Questions

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Which one(s) of the following drugs appear effective in treatment as well as prevention of influenza viral infections.
1. Oseltamivir (Tamiflu)
2. Zidovudine (Retrovir)
3. Rimantadine (Flumadine)
4. Ritonovir (Norvir)
5. A & B
6. B & C
7. A & C
8. A, B & C
Mechanism of action: amantadine and rimantadine
1. Alters functionality of the M2 influenza A viral protein, an ion channel protein.
2. May affect viral assembly by changing hemagglutinin processing.
3. Both
4. Neither
Primary mechanism for resistance to the pharmacological efficacy of amantadine and rimantadine involves an RNA mutation for the M2 protein.
1. True
2. False
Depends on liver metabolism for elimination.
1. Amantadine
2. Rimantadine
Amantadine:
1. Mostly excreted as the parent compound in the urine.
2. Half-life of elimination is increased in elderly compared young adults by about double.
3. Both
4. Neither
Rimantadine is acted upon both by phase 1 and phase 2 reactions (cytochrome P450 metabolism and conjugation reactions)
1. True
2. False
With respect to amantadine, elderly patients typically require a doubling of the drug dose compared to young adults in order to achieve appropriate results.
1. True
2. False
Most common side affects/effects associated with rimantadine and amantadine administration: slight dose-related central nervous system and gastrointestinal effects.
1. True
2. False
Usually better tolerated in residents of nursing homes:
1. Rimantadine
2. Amantadine
Worsening of psychiatric symptoms or previous Italy existing seizure disorders may be more likely to occur with:
1. Amantadine
2. Rimantadine

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Source Material:

Acosta EP Chapter 62 Antiviral Agents (Nonretroviral) in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.

Safrin S Chapter 49 Antiviral Agents in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.

Li JZ Coen DM Chapter 38 Pharmacology of Viral Infections in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy 4e (Golan DE Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.

Waller DB Sampson AP Section 11 Chemotherapy in Medical Pharmacology & Therapeutics Elsevier 2018.

Burchum JR Rosenthal LD Chapter 97 Antiviral Agents I: Drugs for Non-HIV Viral Infections in Lehne's Pharmacology for Nursing Care Elsevier 2022.

Waller DB Sampson AP Section 11: Chapter 51 Chemotherapy of infections in Medical Pharmacology & Therapeutics Elsevier 2018.

Benavides S Bahal O'Mara N Nahata MC Chapter 79 Viral Infections in Applied Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.

Davanathan AS Symonds AE Adams JL Cottrell ML Chapter 76 Pharmacotherapy of Human Immunodeficiency Virus Infection in Applied Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.