Medical Pharmacology: Antiviral Drug Practice Questions
Click on the correct answer.
Zidovudine (AZT) side effect/effects:
Bone marrow suppression
Skeletal myopathy
Both
Neither
Zidovudine and bone marrow suppression:
Because zidovudine administration may result in bone marrow suppression, this agent should be administered with caution in the presence of pre-existing anemia.
Cautious use of zidovudine in patients taking other medications that suppress bone marrow function, given that zidovudine also suppresses bone marrow function.
Both
Neither
Zidovudine and stavudine (Zerit):
These drugs compete for intracellular phosphorylation.
These agents should not be administered at the same time.
Both
Neither
Lamivudine (Epivir):
Active only against HIV-1
Active against hepatitis B virus (HBV)
Both
Neither
Lamivudine (Epivir):
Classified as a cytidine analog reverse transcriptase inhibitor.
May be used effectively in combination with other HIV antiretroviral drugs.
Both
D-either
The active metabolite of lamivudine is the triphosphate form, lamivudine-5'-triphosphate.
True
False
Lamivudine exhibits high affinity for both viral and human DNA polymerases.
True
False
Primary excretion mechanism for lamivudine:
Hepatic metabolism
Renal excretion
Pulmonary elimination
Lamivudine is an antiretroviral drug with comparatively limited toxicity compared to other antiretrovirals.
True
False
Lamivudine and hepatitis B virus: Since lamivudine is effective in treating hepatitis due to HBV, sudden discontinuation of lamivudine may lead to a worsening of hepatitis due to an increase in HBV replication.
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Source Material:
Acosta EP Chapter 62 Antiviral Agents (Nonretroviral)
in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Safrin S Chapter 49 Antiviral Agents in
Basic & Clinical Pharmacology (Katzung BG, Editor;
Vanderah TW, Associate editor) 15e McGraw Hill 2021.
Li JZ Coen DM Chapter 38 Pharmacology of
Viral Infections in Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy 4e (Golan DE
Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.
Waller DB Sampson AP Section 11
Chemotherapy in Medical Pharmacology & Therapeutics
Elsevier 2018.
Burchum JR Rosenthal LD Chapter 97
Antiviral Agents I: Drugs for Non-HIV Viral Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
Waller DB Sampson AP Section 11: Chapter
51
Chemotherapy of infections in Medical Pharmacology & Therapeutics
Elsevier 2018.
Benavides S Bahal O'Mara N Nahata MC
Chapter 79 Viral Infections in Applied Therapeutics:
The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
Davanathan AS Symonds AE Adams JL
Cottrell ML Chapter 76 Pharmacotherapy of Human
Immunodeficiency Virus Infection
in Applied
Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
Flexner CW Chapter 64 Antiretroviral
Agents and Treatment of HIV Infection
in Goodman &
Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Burchum JR Rosenthal LD Chapter
98
Antiviral Agents II: Drugs for HIV Infection and Related
Opportunistic Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
