Medical Pharmacology: Antiviral Drug Practice Questions

Medical Pharmacology: Antiviral Drug Practice Questions

Click on the correct answer.

Tenofovir disoproxil fumerate (TDF, Viread): a nucleotide reverse transcriptase inhibitor
1. True
2. False
Tenofovir is a prodrug:
1. Available as the disoproxil formulation
2. Available as the alafenamide formulation
3. Both
4. Neither
Tenofovir exhibits antiviral activity with respect to which one(s) of the following?
1. HIV-1
2. HSV-2
3. HBV (Hepatitis B Virus)
4. A & B
5. B & C
6. A & C
7. A, B & C
Tenofovir disoproxil fumarate (TDF):
1. FDA approved for treating HIV in adults.
2. FDA approved for treating HIV in children >2 years old.
3. Used in combination with other antiretrovirals.
4. A & B
5. B & C
6. A & C
7. A, B & C
Tenofovir disoproxil fumarate (TDF): when administered in combination with emtricitabine (Emtriva) the combination may be used for "HIV preexposure prophylaxis."
1. True
2. False
Tenofovir alafenamide (TAF), in addition to treating HIV and HBV, this agent in combination with emtricitabine may be used for HIV prophylaxis.
1. True
2. False
Tenofovir disoproxila fumerate (Viread):
1. Water-soluble prodrug
2. Oral bioavailability: about 25% (fasting) to about 40% following a meal high in fat.
3. Both
4. Neither
Tenofovir disoproxil fumarate (Viread) elimination:
1. Glomerular filtration
2. Active tubular secretion
3. Both
4. Neither
Tenofovir disoproxil fumarate (Viread): An example of a NRTI-class agent recommended for administration to a pregnant patient.
1. True
2. False
Tenofovir disoproxila fumerate (Viread) is a prodrug which is intracellularly converted to an active form, tenofovir diphosphate.
1. True
2. False
Tenofovir disoproxil fumarate mechanism(s) of antiviral action:
1. Inhibition of HIV reverse transcriptase by competitive inhibition.
2. Promotes chain termination following incorporation into DNA.
3. Both
4. Neither
Prior to the phosphorylation steps, tenofovir disoproxil fumerate is first hydrolyzed to tenofovir.
1. True
2. False
Tenofovir diphosphate activity against polymerases:
1. Tenofovir diphosphate exhibits high affinity for viral DNA polymerases.
2. Tenofovir diphosphate shows comparatively lower affinity for human DNA polymerase.
3. Both
4. Neither

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Source Material:

Acosta EP Chapter 62 Antiviral Agents (Nonretroviral) in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.

Safrin S Chapter 49 Antiviral Agents in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.

Li JZ Coen DM Chapter 38 Pharmacology of Viral Infections in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy 4e (Golan DE Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.

Waller DB Sampson AP Section 11 Chemotherapy in Medical Pharmacology & Therapeutics Elsevier 2018.

Burchum JR Rosenthal LD Chapter 97 Antiviral Agents I: Drugs for Non-HIV Viral Infections in Lehne's Pharmacology for Nursing Care Elsevier 2022.

Waller DB Sampson AP Section 11: Chapter 51 Chemotherapy of infections in Medical Pharmacology & Therapeutics Elsevier 2018.

Benavides S Bahal O'Mara N Nahata MC Chapter 79 Viral Infections in Applied Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.

Davanathan AS Symonds AE Adams JL Cottrell ML Chapter 76 Pharmacotherapy of Human Immunodeficiency Virus Infection in Applied Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.

Flexner CW Chapter 64 Antiretroviral Agents and Treatment of HIV Infection in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.

Burchum JR Rosenthal LD Chapter 98 Antiviral Agents II: Drugs for HIV Infection and Related Opportunistic Infections in Lehne's Pharmacology for Nursing Care Elsevier 2022.