Medical Pharmacology: Antiviral Drug Practice Questions
Enfuvirtide (Fuzeon)
Figure Attribution:
Fauci
AS Folkers GK Land HC Chapter 202 Human Immunodeficiency
Virus Disease: AIDS and Related Disorders in
Harrison's Principles of Internal Medicine, 21 e (Loscalzo J
Kasper DL Longo DL Fauci AS Hauserf SL Jameson JL, eds)
McGraw Hill 2022. (Modified from Figure 202-46:
Molecular structures of antiretroviral agents.
Click on the correct answer.
Enfurvirtide (Fuzeon):
Peptide
Protein
Small-molecule drug
None of the above
Activity of Enfurvirtide:
Efficacious with respect to clinical HIV-1 isolates.
Effective with respect to clinical HIV-2 isolates.
Effective with respect to clinical HCV isolates (hepatitis C).
A & B
B & C
A & C
A, B & C
Enfuvirtide (Fuzeon) binding:
To gp120
To gp160
To gp41
Enfuvirtide (Fuzeon) has obtained FDA approval for use in which one/ones of the following?
Treatment-naïve adults
Treatment-naïve children
Both
Neither
Factor/factors which tend to limit enfuvirtide use to patients without other treatment options:
Cost
Route of administration
Both
Neither
The amino acid sequence of enfuvirtide is related to the HIV-1 transmembrane protein subunit gp41.
True
False
Enfuvirtide (Fuzeon) will prevent free HIV virus particles from infecting CD4+ cells.
True
False
Enfuvirtide:
Enfuvirtide will likely maintain activity against HIV-viral strains that exhibit resistance to antiviral drugs from other antiretroviral drug classes.
Enfuvirtide is not subject to mutation-mediated resistance.
Both
Neither
Enfuvirtide is used in conjunction with other drugs in treatment-experienced individuals who exhibit HIV-1 replication even during ongoing antiretroviral treatment.
True
False
Enfuvirtide pharmacokinetics: Enfuvirtide bioavailability administered subcutaneously is almost the same as that which is observed after an IV dose.
True
False
The relatively short elimination half-life of subcutaneous
enfuvirtide is about 4 hours, thus requiring twice-daily dosing.
True
False
Enfuvirtide administration:
Most notable adverse effect refer to injection-site reactions
Enfuvirtide administration appears associated with a higher incidence of lymphadenopathy and pneumonia.
If you wish to return to the Table of Contents
in ENGLISH, press the RETURN button above.
Otherwise, if the text is NOT displayed in
English and you are ready to leave this page,
Press here
to return to the Table of Contents
Source Material:
Acosta EP Chapter 62 Antiviral Agents (Nonretroviral)
in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Safrin S Chapter 49 Antiviral Agents in
Basic & Clinical Pharmacology (Katzung BG, Editor;
Vanderah TW, Associate editor) 15e McGraw Hill 2021.
Safrin S Chapter 49 Antiviral Agents in
Katzung's Basic & Clinical Pharmacology (Vanderah TW editor) 16e McGraw Hill 2023.
Li JZ Coen DM Chapter 38 Pharmacology of
Viral Infections in Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy 4e (Golan DE
Armstong EJ Armstrong AW, eds) Wolters Kluwer 2017.
Burchum JR Rosenthal LD Chapter 97
Antiviral Agents I: Drugs for Non-HIV Viral Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
Waller DB Sampson AP Section 11: Chapter
51
Chemotherapy of infections in Medical Pharmacology & Therapeutics
Elsevier 2018.
Benavides S Bahal O'Mara N Nahata MC
Chapter 79 Viral Infections in Applied Therapeutics:
The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
Burchum JR Rosenthal LD Chapter
98
Antiviral Agents II: Drugs for HIV Infection and Related
Opportunistic Infections
in Lehne's Pharmacology for Nursing Care Elsevier 2022.
Davanathan AS Symonds AE Adams JL
Cottrell ML Chapter 76 Pharmacotherapy of Human
Immunodeficiency Virus Infection
in Applied
Therapeutics: The Clinical Use of Drugs (Zeind C, Carvalho MG Cheng JW
Zaiken K Lapointe T, eds) Wolters Kluwer, 2024.
Flexner CW Chapter 64 Antiretroviral
Agents and Treatment of HIV Infection
in Goodman &
Gilman's: The Pharmcological
Basis of Therapeutics, 14e, (Brunton LL Knollmann BC eds) McGraw-Hill Education, 2023.
Fauci AS Folkers GK Land HC Chapter
202 Human Immunodeficiency Virus Disease: AIDS and
Related Disorders in Harrison's Principles of Internal
Medicine, 21 e (Loscalzo J Kasper DL Longo DL Fauci AS
Hauserf SL Jameson JL, eds) McGraw Hill 2022.
