Medical Pharmacology Chapter 5: Pharmacology of Adrenergic Drugs

Effects of epinephrine and smooth muscle associated with different systems organs is dependent on the subtype of adrenergic receptor in the muscle.
1. True
2. False
The typical effect of epinephrine on gastrointestinal smooth muscle:
1. Constriction
2. Relaxation
Uterine Smooth muscle response to epinephrine
1. Dependent on state of gestation, phase of sexual cycle and dose
2. Epinephrine inhibits serotonin contraction during last month of pregnancy.
3. Both
4. Neither
Epinephrine and bladder smooth muscle effect(s):
1. Detrusor muscle relaxation due to β-adrenergic receptor activation.
2. Contraction of trigone and sphincter muscle as a result of α-adrenergic receptor subtype activation.
3. Both
4. Neither
Autonomic effect: radial muscle, Iris
1. No appreciable parasympathetic activity
2. Sympathetic effect is contraction (mydriasis)
3. Both
4. Neither
Autonomic effect: ciliary muscle of the eye:
1. Relaxation for far vision is the sympathetic-mediated response (β₂)
2. Parasympathetic effect is contraction for near vision (M₂, M₃ muscarinic receptor subtype mediated)
3. The sympathetic, adrenergic effect is the predominant effect
4. A & B
5. B & C
6. A & C
7. A, B & C
Autonomic effect on lachrymal glands:
1. Sympathetic effect mediates secretion by means of α receptor subtype activation.
2. Parasympathetic effect mediates secretion by means of activation of M₃, M₂-type muscarinic, cholinergic receptors
3. Both
4. Neither
Autonomic effect on the SA node in the heart:
1. The sympathetic effect is to increase heart rate; this effect is primarily mediated by β₁ (β₁ >β₂).
2. No parasympathetic effect is present.
3. Both neither
Autonomic effect at the atrioventricular (AV node):
1. The sympathetic effect is one that increases both conduction velocity and automaticity with the β₁ effect predominating.
2. The parasympathetic action is to decrease conduction velocity and to promote blockade at the AV node. The parasympathetic effect is the predominant action.
3. Both
4. Neither
Autonomic effect on the atria:
1. The sympathetic effect is to increase heart rate by means of activation of the β₁ adrenergic receptor subtype.
2. The parasympathetic effect is to reduce contractility and decreased the action potential duration. With respect to contractility, the parasympathetic effect dominates.
3. Both
4. Neither