Question # 1 (Multiple Choice) Nonselective alpha-adrenergic receptor antagonist(s)

A) phentolamine (Regitine)
B) prazosin (Minipress)
C) yohimbine (Yocon)

Question # 2 (Multiple Choice) "Epinephrine reversal" could occur if epinephrine is administered in the presence of:

A) cocaine
B) imipramine (Tofranil)
C) propranolol (Inderal)
D) phentolamine (Regitine)
E) dopamine (Intropin)

Question # 3 (Multiple Choice) Catecholamine desensitization: regulation of catecholamine responsiveness occurs at:

A) receptors
B) G protein
C) adenylyl cyclase
D) cyclic nucleotide phosphodiesterase
E) all the above

Question # 4 (Multiple Choice) Drugs used to manage allergic reactions:

A) glucocorticoids
B) antihistamines
C) subcutaneous epinephrine
D) all the above

Question # 5 (Multiple Answer) Drugs which may be used to terminate paroxysmal supraventricular tachycardia:

A) adenosine (Adenocard)
B) calcium channel blockers
C) esmolol (Brevibloc)
D) methoxamine (Vasoxyl)

Question # 6 (Multiple Answer) Clinical conditions that may result in shock:

A) dehydration or blood loss
B) cardiac failure
C) cardiac output obstruction
D) loss of peripheral vascular tone

Question # 7 (Multiple Choice) Correct order of adrenergic beta-agonist potency (greatest to least)

A) isoproterenol, norepinephrine, epinephrine
B) norepinephrine, epinephrine, isoproterenol
C) epinephrine, isoproterenol, norepinephrine
D) isoproterenol, epinephrine, norepinephrine

Question # 8 (Multiple Choice) Alpha receptor class activated by drugs such as clonidine:

A) alpha1
B) alpha2

Question # 9 (Multiple Answer) Enzyme(s) that degrade catecholamines:

A) MAO (monoamine oxidase)
B) dopamine beta-hydroxylase
C) tyrosine hydroxylase
D) dopa decarboxylase
E) COMT (catechol-O-methyltransferase)

Question # 10 (Multiple Choice) Beta adrenergic receptor class found mainly in smooth muscle and most other noncardiac sites:

A) beta1
B) beta2
C) beta3

Question # 11 (Multiple Choice) Enzyme catalyzing the conversion of norepinephrine to epinephrine:

A) dopamine beta-hydroxylase
B) phenylethanolamine N-methyltransferase
C) tyrosine hydroxylase
D) dopa decarboxylase

Question # 12 (Multiple Answer) Drugs that block translocation of norepinephrine from extraneuronal sites into the cytoplasm: (Uptake I inhibitors) --

A) imipramine (Tofranil)
B) amitriptyline (Elavil, Endep)
C) desipramine (Norpramin)
D) protriptyline (Vivactil)
E) cocaine

Question # 13 (Multiple Choice) Termination of norepinephrine effect is mainly due to:

A) metabolism
B) diffusion of norepinephrine away from receptors
C) reuptake into presynaptic nerve terminals
D) water-catalyzed hydrolysis

Question # 14 (Multiple Choice) Competitive antagonist in both alpha1 and alpha2 receptor sites; also block serotonin receptors

A) esmolol (Brevibloc)
B) labetalol (Trandate, Normodyne)
C) phentolamine (Regitine)
D) yohimbine (Yocon)
E) prazosin (Minipress)

Question # 15 (Multiple Choice) Alpha adrenergic antagonist more potent at alpha2 compared alpha1 adrenergic receptors:

A) phentolamine (Regitine)
B) prazosin (Minipress)
C) yohimbine (Yocon)

Question # 16 (Multiple Choice) Beta adrenergic receptor class found mainly in myocardial tissue:

A) beta1
B) beta2

Question # 17 (Multiple Choice) Most abundant catecholamine in the adrenal medulla:

A) isoproterenol
B) dopamine
C) amphetamine
D) norepinephrine
E) epinephrine

Question # 18 (Multiple Choice) Phosphorylation of tyrosine hydroxylase has its effect on tyrosine hydroxylase activity:

A) increase
B) decrease
C) no effect

Question # 19 (Multiple Answer) Physiological consequences alpha-2 receptor activation:

A) contraction of arterial smooth muscle
B) increased vagal tone
C) decreased sympathetic outflow
D) decreased insulin release
E) contraction of venular smooth muscle

Question # 20 (Multiple Answer) Drugs used in cardiogenic shock treatment:

A) adrenergic agonists
B) nitrates
C) amrinone (Inocor)

Question # 21 (Multiple Choice) Primary objective in pharmacological management of shock:

A) maintain adequate renal perfusion
B) maintain adequate CNS perfusion
C) maintain adequate hepatic perfusion

Question # 22 (Multiple Choice) Order of alpha-adrenergic agonist potency (greatest to least):

A) norepinephrine, isoproterenol, epinephrine
B) isoproterenol, norepinephrine, epinephrine
C) epinephrine, norepinephrine, isoproterenol
D) isoproterenol, epinephrine, norepinephrine
E) norepinephrine, epinephrine, isoproterenol

Question # 23 (Multiple Choice) Rate-limiting step been catecholamine biosynthesis is catalyzed by this enzyme:

A) dopa decarboxylase
B) phenylethanolamine N-methyltransferase
C) tyrosine hydroxylase
D) dopamine beta-hydroxylase

Question # 24 (Multiple Choice) Alpha-adrenergic receptors found primarily postsynaptically:

A) alpha1
B) alpha2

Question # 25 (Multiple Choice) Consequence of beta-adrenergic receptor phosphorylation:

A) enhanced receptor responsiveness
B) decreased receptor responsiveness