Medical Pharmacology: Antiarrhythmic Drugs
Practice Questions
Click on the correct answer.
Characteristics of class 3 antiarrhythmic drugs exhibit which one(s) of the following characteristics?
Prolongation of the cardiac action potential duration
Often block the fast component of the delayed rectifier potassium current, IKr.
Both
Neither
Class I antiarrhythmic drugs affect primarily this ion-channel
Potassium
Calcium
Sodium
Chloride
Which drug subclass of class I antiarrhythmic agents mainly increase action potential duration and exhibit "intermediate kinetics" in dissociation from the channel.
Class IA
Class IB
Class IC
Which drug subclass of class I antiarrhythmic agents mainly shorten the cardiac action potential duration and some cardiac tissues and exhibit "rapid kinetics" describing drug dissociation from the channel.
Class IA
Class IB
Class IC
Which drug subclass of class I antiarrhythmic agents mainly exhibit limited effects on the cardiac action potential duration and show "slow kinetics" with respect to drug-receptor dissociation.
Class IA
Class IB
Class IC
Drugs associated with this antiarrhythmic drug class decrease cardiac ß-adrenergic activity.
Class 1
Class 2
Class 3
Class 4
Drugs associated with this antiarrhythmic drug class are associated with cardiac action potential duration prolongation.
Class 1
Class 2
Class 3
class 4
Drugs associated with this antiarrhythmic drug class mainly block cardiac calcium currents. These agents are associated with reduced (slower) conduction in specialized cardiac tissue such as the SA and AV nodes where the action potential upstroke is dependent on Calcium channel activation.
Class 1
Class 2
Class 3
Class 4
Example(s) of (an) antiarrhythmic drug(s) that do not fit the Class 1 - Class 4 categorization include(s):
Magnesium
Adenosine
Both
Neither
The antiarrhythmic drug amiodarone exhibits properties characteristic of all 4 antiarrhythmic drug classes.
