Medical Pharmacology Practice Questions: Antiarrhythmic Drugs

Antiarrhythmic drugs that belong to this class has the effect of increasing the duration of the effective refractory period by prolonging the action potential
1. Class 1
2. Class 2
3. Class 3
4. Class 4
The ionic current affected mainly by classes3 drugs which prolonged effective refractory period is:
1. Sodium-channel
2. Chloride channel
3. Potassium channel
4. Calcium channel
Action potential prolongation by class 3 drugs tend to be most noted at fast heart rate.
1. True
2. False
Choose which one(s) of the following statements is/are correct.
1. Class 3 antiarrhythmic drugs cause QT prolongation.
2. Some class 3 agents more than others result in torsades de points, even if an agent less likely to cause this arrhythmia still exhibits notable Q-T-prolongation.
3. Substantial QT prolongation by itself may not be the best predictor drug-induced torsades.
4. A & C
5. A & C
6. B only
7. A, B & C
Ibutilide is principally categorized as a member of this drug class.
1. Class I
2. Class 2
3. Class 3
4. Class 4
Ibutilide exhibit(s) the following electrophysiological activity/activities:
1. Antagonism of the ILr current
2. Enhancement of the late, slow inward sodium current
3. Both
4. Neither
Ibutilide exhibits which one(s) of the following effects?
1. QT prolongation
2. Notable effects at the SA node
3. Significant slowing of conduction to the AV node
4. A & C
5. B & C
6. A, B & C
Ibutilide is administered typically by which one(s) of the following routes of administration?
1. Oral
2. Intramuscular
3. Intravenous
4. A & B
Ibutilide, exhibiting a half-life of 2-12 hours, is metabolized extensively by the liver to metabolites which are mainly eliminated by the kidney.
1. True
2. False
Considering the clinical indications for ibutilide administration, choose the correct statement(s)
1. Ibutilide is indicated for acute termination of atrial flutter and fibrillation.
2. The effectiveness of ibutilide is enhanced for arrhythmias of short-duration.
3. Ibutilide may be helpful in converting atrial fibrillation to sinus rhythm both in patients following cardiac surgery and in patients exhibiting Wolff-Parkinson-White syndrome
4. A & C
5. A & B
6. B only
7. A, B & C
The primary adverse reaction to ibutilide is:
1. Negative Inotropism (reduced myocardial contractility)
2. Transient renal dysfunction
3. torsades de pointes
4. Atrial flutter
d, l sotalol contains both the d- and l- isomers in equal proportion (racemate) with both isomers exhibiting antiarrhythmic behavior.
1. True
2. False
Antiarrhythmic activity of sotalol is due to inhibition of this ion-channel.
1. Sodium
2. Potassium (IKr)
3. Chloride
4. Calcium
Sotalol is categorized as a member of this/these antiarrhythmic classes:
1. Class 1
2. Class 2
3. Class 3
4. Class 4
5. A & B
6. B & C
Which of the following statement(s) is/are correct concerning the pharmacokinetics and dosing of sotalol?
1. Sotalol is well absorbed (bioavailability: nearly 100%)
2. Sotalol is eliminated by renal mechanisms unchanged, i.e. as the parent compound.
3. In patients with renal dysfunction, dosage adjustment should be based on patient's creatinine clearance
4. All of the above
A common clinical use of sotalol is preventing atrial fibrillation and ventricular tachycardia recurrence, particularly if these arrhythmias appear related to "old" myocardial infarction
1. True
2. Paul's