Hydralazine (Apresoline) Minoxidil (Loniten) 
  • Vasodilators used for chronic treatment include hydralazine (Apresoline) and minoxidil (Loniten).
    • These drugs are not typically administered as monotherapy due to significant reflex-mediated cardiac stimulation and water retention. Instead they may be combined with sympatholytic drugs.
  • Adverse effects include those induced by vasodilation such as:
  • hypotension
  • palpitation
  • tachycardia
  • fluid retention
  • headache
  • angina
  • A drug-induced lupus syndrome is associated with hydralazine (Apresoline).
  • A drug-induced hypertrichosis is associated with minoxidil (Loniten).