- Antihypertensive effects of
propranolol (Inderal) are due to
- (1) Decreased myocardial
contractility and rate and
- (2) To consequences of
decreased renin secretion. Both effects
occur as a consequence of ß-adrenoceptor blockade
- Decreased renin levels
lead to decreases in circulating
angiotensin II and effects on aldosterone
levels.
- Propranolol (Inderal) is
an example of a non-selective beta
blocker, antagonizing both ß1
(cardiac) and ß2 (extra-cardiac)
sites.
- ß receptor
blockade cause:
- decreases
in myocardial contractility
- increases
in serum triglycerides and decreases in HDL
cholesterol levels
- increases
in bronchial smooth muscle tone
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