Tocainide [toe kay' nide]
(Class I, Sodium Channel Blocker)

  • Analog of lidocaine, but with reduced first-pass metabolism.

  • Used for treatment of ventricular arrhythmias

  • Suitable for oral administration, but RARELY USED due to possibly fatal bone marrow aplasia and pulmonary fibrosis.

  • Similar electrophysiologically to lidocaine

  • Tremor and nausea are major dose-related adverse side effects

  • Excreted by the kidney, accordingly dose should be reduced in patients with renal disease.

  • Combination with quinidine may increase efficacy and diminish adverse effects.


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