Amiodarone [a mee' oh da rone]
(Class I and III Channel Blocker)

  • Used in patients with ventricular tachycardia or fibrillation resistant to treatment with other drugs.

  • Effective inhibitor of abnormal automaticity.

  • Blocks sodium and potassium channels and prolongs action potential duration.

  • Most serious adverse effect seen in long-term therapy is a rapidly progressive pulmonary fibrosis which may be fatal

  • Potent inhibitor of hepatic metabolism or renal elimination of many drugs.

  • Warfarin, quinidine, procainamide and digoxin are examples of drugs which may require dosage reduction during amiodarone administration.


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