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Disopyramide [di so peer' a mide]
(Class I Channel Blocker)

  •   Electrophysiological effects similar to quinidine

  •  Prescribed to maintain normal sinus rhythm in patients prone to atrial fibrillation and flutter and is also used to prevent ventricular fibrillation or tachycardia.

  •  Adverse side-effect profile

  •   This agent is different from qunidine's in that disopyramide is not an alpha-adrenergic receptor blocker but is anti-vagal.

  • Disopyramide depresses contractility which may lead to congestive heart failure

  •  Disopyramide can cause torsades de pointes, a ventricular arrhythmia

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