[pra' zoe sin],[ter ay' soe sin]

  • Prazosin, terazosin, and doxazosin reduce arteriolar resistance and increase venous capacitance as a consequence of alpha1 adrenergic receptor blockade. The short-term increase in heart rate and plasma renin levels do not persist although the vasodilation continues.

  • Renal blood flow is maintained.

  • Retention of salt and water occurs.

  • Alpha1-adrenergic receptor blockers reduce plasma triglycerides, total and LDL-cholesterol, and increase HDL-cholesterol.

  • Adverse Effect:

    • Inital-dose marked orthostatic hypotension is seen in about 50% of cases.

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