Previous Page

Procainamide [pro kane a' myde]
(Class IA, Sodium Channel Blocker)

  • Electrophysiological effects are similar to quinidine.

  • By contrast to quinidine, procainamide does not exhibit either vagolytic or alpha-adrenergic blocking activity.

  • Useful in acute management of supraventricular and ventricular arrhythmias.

  • Long term use is associated with side effects, including a drug-induced lupus syndrome which occurs at a frequency of 25% to 50%.

    • In slow acetylators the procainamide-induced lupus syndrome occurs more frequently and earlier in therapy than in rapid acetylators.


Previous Page