Medical Pharmacology Antidepressant Practice Exam Questions

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Antidepressant therapeutic effects may not be seen for two to four weeks:
1. serotonin-specific reuptake inhibitors (SSRIs)
2. tricyclics antidepressants
3. both
4. neither
Buspirone:
1. is effective in treating depression
2. is cross-tolerant with benzodiazepines
3. does not produce significant levels of sedation
4. is a benzodiazepine
5. has a rapid onset of action.
Primary agent used in chronic management of mania in bipolar disorder:
1. sufentanil (Sufenta)
2. lithium
3. valproic acid (Depakene, Depakote)
4. imipramine (Tofranil)
5. paroxetine (Paxil)
Least likely to cause orthostatic hypotension:
1. desipramine (Norpramin)
2. sertraline (Zoloft)
3. doxepin (Sinequan)
4. tranylcypromine (Parnate)
5. amitriptyline (Elavil, Endep)
Administration of an MAO inhibitor would most likely cause changes in the CNS concentration of:
1. acetylcholine
2. histamine
3. norepinephrine
Primary use of fluoxetine (Prozac):
1. treating obsessive-compulsive disorder
2. management of morbid obesity
3. treating endogenous depression
4. management of alcohol withdrawal
5. treating anxiety
Significant atropine-like effects:
1. paroxetine (Paxil)
2. imipramine (Tofranil)
3. both
4. neither
Helpful in treating endogenous depression:
1. tranylcypromine (Parnate)
2. amitriptyline (Elavil, Endep)
3. fluoxetine (Prozac)
4. imipramine (Tofranil)
5. all of the above
Second-generation antidepressant:
1. doxepin (Sinequan)
2. amitriptyline (Elavil, Endep)
3. venlafaxine (Effexor)
4. imipramine (Tofranil)
5. selegiline (Eldepryl)
Low potential for anticholinergic side effects:
1. amitriptyline (Elavil, Endep)
2. amoxapine (Asendin)
3. desipramine (Norpramin)
4. imipramine (Tofranil)
5. sertraline (Zoloft)
Characteristics of lithium toxicity:
1. tremor
2. diabetes insipidus
3. hypothyroidism
4. changes in the electrocardiogram
5. all of the above
Imipramine (Tofranil):
1. miosis
2. increased urinary frequency
3. orthostatic hypotension
4. bradycardia
5. CNS stimulation (increased alertness)
Therapeutic use(s) of antidepressants include(s):
1. severe anxiety disorder
2. post-traumatic stress disorder
3. panic-agoraphobia
4. endogenous depression
5. all of the above
Most likely to be effective in treating obsessive-compulsive disorder:
1. imipramine (Tofranil)
2. doxepin (Sinequan)
3. clomipramine (Anafranil)
4. amitriptyline (Elavil, Endep)
5. phenelzine (Nardil)
Side effects of this antidepressant include nausea, vomiting, and insomnia:
1. tranylcypromine (Parnate)
2. fluoxetine (Prozac)
3. imipramine (Tofranil)
4. amitriptyline (Elavil, Endep)
5. doxepin (Sinequan)
Antidepressant with relatively few cardiovascular side effects:
1. phenelzine (Nardil)
2. paroxetine (Paxil)
3. amitriptyline (Elavil, Endep)
4. maprotiline (Ludiomil)
5. protriptyline (Vivactil)
Therapeutic index similar to that of digitalis:
1. fluoxetine (Prozac)
2. paroxetine (Paxil)
3. lithium
4. sertraline (Zoloft)
5. diazepam (Valium)