Medical Pharmacology Practice Questions: Anti-Seizures; Anti-Epileptic Drugs

Lacosamide (Vimpat) approved in both Europe and the United States for partial seizure management.
1. True
2. False
Lacosamide direct site of action:
1. GABA receptors
2. Glutamate receptors
3. Both
4. Neither
Lacosamide clinical use: adjunct drug for treating partial-onset seizures (+/- secondary generalization).
1. True
2. False
Choose the correct statement(s) concerning lamotrigine (lamictal):
1. Lamotrigine is similar to phenytoin in mechanism of action.
2. Lamotrigine decreases sustained neuronal rapid firing.
3. Lamotrigine causes both a voltage-and use-dependent sodium-channel block
4. A & B
5. B & C
6. A & C
7. A, B & C
Most likely explanation(s) explaining lamotrigine efficacy in managing childhood primary generalized seizures, including absence seizures.
1. Lamotrigine antagonistic effects on sodium channels
2. Lamotrigine in addition to voltage-gated calcium channels (N-and P/Q-type channels)
3. Both
4. Neither
Lamotrigine is effective as monotherapy (single-drug) treatment for partial seizures.
1. True
2. False
Which one(s) of the following seizure types may be effectively managed by lamotrigine?
1. Absence seizures in children
2. Myoclonic seizures in children
3. Partial seizures
4. All of the above
Levetiracetam (Keppra and others) clinical application(s):
1. As an adjunct drug for managing partial seizures.
2. Myoclonic seizures
3. Tonic-clonic seizures
4. All of the above
Levetiracetam probably influences glutamate and GABA synaptic release by action on a specific synaptic vesicle proteins (SC2A).
1. True
2. False
Concerning levetiracetam pharmacokinetics, choose the correct statement(s):
1. Rapid oral absorption
2. Significantly affected by food, should be taken on an empty stomach
3. Most of the drug excreted in the urine unchanged.
4. A & B
5. B & C
6. & C