Medical Pharmacology Practice Questions: Local Anesthetics

Allergic reactions to local anesthetic administration include(s):
1. Urticaria
2. Anaphylaxis
3. Contact dermatitis
4. Administration site swelling
5. A & B
6. A & C
7. A & C
8. B & C
9. A, B, C & D
All of the following local anesthetics are classified as "amide drugs" EXCEPT:
1. Lidocaine
2. Benzocaine
3. Bupivacaine
4. Mepivacaine
Frequently used agent(s) for subcutaneous local anesthesia include(s):
1. Procaine
2. Lidocaine
3. Mepivacaine
4. Bupivacaine
5. All of the above
Systemic absorption of local aesthetic agents from administration sites is affected by which one(s) of the following:
1. Drug dosage
2. Local tissue blood flow
3. Presence of epinephrine in the local anesthetic solution
4. All of the above
In comparing these two local anesthetic blocks,which one is associated with a higher anesthetic serum levels?
1. Sciatic and femoral blockade
2. Intercostal blockade
Reduce systemic absorption rate due to the addition of vasoconstrictors with local anesthetics is most typically noted with shorter-acting, less lipid-soluble and less potent agents.
1. True
2. False
Local anesthetics delivered into the subarachnoid space will exhibit a distribution pattern most importantly dependent on specific gravity compared to that of the cerebrospinal fluid as well as the patients position (anesthetic solutions may be hyperbaric, hyperbaric or isobaric)
1. True
2. False
This type of local anesthetic is more likely to be converted to water-soluble metabolites in plasma.
1. Amide-type
2. Ester-type
Amide-type local anesthetics undergo hepatic biotransformation involving hydroxylation and N-dealkylation catalyzed by the cytochrome P450 drug metabolizing system.
1. True
2. False
Fastest rate of hepatic metabolism:
1. Bupivacaine
2. Ropivacaine
3. Lidocaine
4. Prilocaine