Medical Pharmacology Practice Questions: Opioid Analgesics

Which one(s) of the following represent families of endogenous opioid peptides?
1. Endorphins
2. Dynorphins
3. Enkephalins
4. A & B
5. A & C
6. A, B & C
Enkephalins are derived from which large precursor protein?
1. Preproopiomelanocortin (POMC)
2. Preproenkephalin
3. Preprodynorphin
Preproopiomelanocortin (POMC) sequence is associated with non-opioid peptides including which one(s) of the following?
1. Adrenocorticotropic hormone
2. Melanocyte stimulating hormone
3. ß-lipotropin
4. Vasoporessin
5. A & B
6. A & C
7. A,B & C
8. A, B, C & D
ß-endorphin is derived from cleavage of ß-lipotropin.
1. True
2. False
Principal CNS site(s) of POMC (proopiomelanocortin) producing cells include(s):
1. Basal ganglia
2. Hypothalamus (arcuate nucleus)
3. Nucleus tractus solitarius
4. A & B
5. A & C
6. B & C
7. A, B & C
Proenkephalin consists of a single copy of leu-enkephalin and several copies of met-enkephalin.
1. True
2. False
Some proenkephalin peptide localization(s):
1. Spinal trigeminal nucleus
2. Spinal cord (laminae I & II)
3. Periaqueductal gray
4. All of the above
These anatomical sites are related to affective behavior modulation and are sites where proenkephalin peptides are present.
1. Frontal cerebral cortex
2. Locus ceruleus
3. Hippocampus
4. Amygdala
5. A & B
6. A & C
7. A, B, C & D
Prodynorphin consists of three peptides: dynorphins A, dynorphins B and neoendorphin.
1. True
2. False
Nociceptin peptide is and neuronal peptide distributed mainly in cortex, brainstem, and hippocampus.
1. True
2. False