Medical Pharmacology: Opioid Analgesic Practice
Questions
Click on the correct answer.
Methadone is classified as a long-acting mu opioid receptor agonist with activities comparable to those seen with morphine.
True
False
Analgesic effects associated with methadone is mainly a consequence of:
The L-Methadone isomer
The D-methadone isomer
Both
Pharmacological properties/property associated with methadone include/includes:
Pharmacological effects following oral administration
Suppression of withdrawal symptoms and physically dependent patients over an extended period of time.
Effective even with repeated dosing
A & B
B & C
A. B & C
Methadone differs from morphine in that methadone does not suppress bowel motility or cough.
True
False
Concerning methadone absorption and metabolism: which of the following statements are statements is/are correct?
Methadone is well absorbed from the G.I. tract.
Methadone exhibit substantial binding to plasma proteins.
Methadone is metabolized extensively by the liver.
A & B
A & C
A, B & C
By contrast other opioids, methadone and ministration appears associated with prolonged cardiac QT syndrome and this effect is additive in patients taking other drugs known to lengthen the QT interval.
True
False
Major clinical uses of methadone:
Management of opioid abstinence effects
Treatment of heroin users
Both
Neither
In the use of oral methadone over the long-term, patients do not exhibit withdrawal effects following naloxone administration.
True
False
D-propoxyphene (Darvon et al.) administration has been associated with a number of toxicities and, as a result, is being replaced in the clinical setting by safer agents.
True
False
In the US, propoxyphene is not recommended in individuals exhibiting suicidal behavior or with a history of suicidal ideation.