Medical Pharmacology Practice Questions: Opioid Anti-Cough (Antitussives) Drugs

Choose the correct statement(s) concerning cough:
1. Angiotensin-converting enzyme inhibitors (ACE) administration can cause cough.
2. In some patients, chronic cough leads to fatigue.
3. Both
4. Neither
Administration of which one(s) of the following agents reduce cough through centrally-mediated activity?
1. Dihydrocodeine
2. Hydrocodone
3. Codeine
4. A & C
5. B
6. A, B & C
Dextromethorphan exhibits neither analgesic or addictive characteristics although its actions are mediated through opioid receptors.
1. True
2. False
Administration of dextromethorphan exhibits less subjective but more G.I. side effects compared to codeine.
1. True
2. False
An example of an antitussive drug used outside the United States is Pholcodine.
1. True
2. False
The mechanism by which dextromethorphan administration produces its antitussive effect has been determined to involve both cholinergic-muscarinic receptors and NMDA receptors.
1. True
2. False
Duration of action of dextromethorphan antitussives effect at typical doses:
1. 1 hour
2. 2-3 hours
3. 5-6 hours
4. >8 hours
Dextromethorphan increases the coughing threshold.
1. True
2. False
In patients with pathological cough dextromethorphan exhibits a potency nearly as great as that of codeine with respect to cough management.
1. True
2. False
"Methorphan" isomer exhibiting both analgesic and addictive features.
1. D-Isomer i. e. Dextromethorphan [D-3-methoxy-N-methylmorphnan]
2. L-isomer [L-3-methoxy-N-methylmorphnan]
3. Both
4. Neither