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Medical Pharmacology Chapter 18:  Antiparkinson's Disease Drug Practice Questions

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Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

    A) too expensive
    B) the problem is cholinergic in nature
    C) dopamine does not cross the blood-brain barrier
    D) levodopa has a higher affinity for the D2 receptor

Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

    A) Wilson's disease
    B) tardive dyskinesia
    C) Tourette's syndrome
    D) Huntington's disease
    E) Shy-Drager syndrome

Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

    A) procyclidine
    B) pergolide
    C) amantadine
    D) levodopa
    E) reserpine

Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

    A) true
    B) false

Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

    A) athetosis
    B) dystonia
    C) tics
    D) chorea
    E) akinesia

Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

    A) levodopa
    B) amantadine
    C) pergolide
    D) selegiline
    E) trihexyphenidyl

Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

    A) Parkinson's disease
    B) Wilson's disease
    C) Shy-Drager syndrome
    D) Tourette's syndrome
    E) all of the above

Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

    A) 1-3%
    B) 5-10%
    C) 15-30%
    D) > 50%

Question # 9 (Multiple Answer) Effective in managing essential tremor

    A) propranolol
    B) metoprolol
    C) primidone
    D) diazepam
    E) chlordiazepoxide

Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

    A) amantadine
    B) levodopa
    C) bromocriptine
    D) selegiline
    E) benztropine mesylate

Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

    A) effective D2 agonist
    B) effective D2 antagonist
    C) effective peripheral decarboxylase inhibitor
    D) effective central decarboxylase inhibitor
    E) :effective competitor at the GABA receptor

Correct Answers

1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11






































Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

Answer: (C) dopamine does not cross the blood-brain barrier

BACK







































Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

Answer: (D) Huntington's disease

BACK







































Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

Answer: (C) amantadine

Anti-Parkinson mechanism of action unclear; knack by affecting dopamine reuptake, synthesis, or release BACK







































Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

Answer: True

BACK







































Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

Answer: (D) chorea

chorea: may be hereditary, secondary to non--neurological disease; drug-induced BACK







































Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

Answer: (C) pergolide

pergolide & bromocriptine are ergot alkaloid derivatives useful in treating Parkinson's disease BACK







































Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

Answer: (D) Tourette's syndrome

BACK







































Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

Answer: (A) 1-3%

most levodopa is metabolized extracerebrally BACK







































Question # 9 (Multiple Answer) Effective in managing essential tremor

(A) propranolol

(B) metoprolol

(C) primidone

probably a beta-adrenergic receptor dysfunction; anti-Parkinson agents, diazepam, chlordiazepoxide, mephenesin not useful BACK







































Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

Answer: (C) bromocriptine

ergot derivative; dopamine agonist, probably at D2 receptors BACK







































Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an:

Answer: (C) effective peripheral decarboxylase inhibitor

BACK