The mechanism of action of "atypical" (antipsychotic agents that exhibit very limited extrapyramidal side effects at therapeutic doses) antipsychotic drugs involve a limited dopamine (D2)-receptor blockade along with a significant serotonin (5-HT2A) blockade appears to applied to all the following agents EXCEPT:

This/these atypical antipsychotic drug(s) exhibit 5-HT2A antagonism but a partial D2-type dopamine receptor agonism.

For patients that did not respond to typical antipsychotic medications, this agent became the first antipsychotic drug which improved both negative and positive symptoms in patients.

Clozapine administration may cause agranulocytosis in about 1% of patients. This factor constrains the patient groups for which clozapine may be appropriate.

Which one(s) of the following statements concerning clozapine is/are correct?

Clozapine has been approved for patients with schizophrenia who present with a high risk for suicide.

Percentage of patients with positive symptoms that may not respond adequately to clozapine monotherapy.

In patients exhibiting substantial treatment-resistance, clozapine therapy lasting six months or longer may be required for positive symptom control (highly treatment-resistant patients).

Clozapine-induced agranulocytosis most typically occurs within this time window following treatment initiation:

Clozapine side effect(s):