• Endometrial carcinoma:

  • Primary drugs:

    • Progestins or tamoxifen (Nolvadex)

  • Other useful drugs/modalities:

    • doxorubicin (Adriamycin)

    • cisplatin (Platinol)

    • carboplatin (Paraplatin) 

• Ovarian cancer:

  • Primary drugs:

    • cisplatin (Platinol)

    • carboplatin (Paraplatin)

  • Other useful drugs/modalities:

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• Cervical cancer:

  • Primary drugs:

    • cisplatin (Platinol)

    • carboplatin (Paraplatin)

  • Other useful drugs/modalities:

• Breast cancer:

  • Primary drugs:

    • Adjuvant chemotherapy or tamoxifen following surgery

    • Combination chemotherapy or hormonal medication for late recurrence

  • Other useful drugs/modalities:

• Choriocarcinoma (trophoblastic neoplasm)

  • Primary drugs:

    • methotrexate

    • etoposide (VP-16,VePe-sid) plus cisplatin (Platinol)

  • Other useful drugs/modalities:

    • vinblastine (Velban)

    •  mercaptopurine (Purinethol)

    • chlorambucil (Leukeran)

    • doxorubicin (Adriamycin)

• Polycythemia vera

  • Primary drugs:

    • busulfan (Myleran)

    • chlorambucil (Leukeran)

    • cyclophosphamide (Cytoxan)

  • Other useful drugs/modalities:

    • Radioactive P ³²

• Testicular cancer:

  • Primary drugs:

    • Combination chemotherapy:

      •  cisplatin (Platinol)

      •  bleomycin (Blenoxane)

      •  etoposide (VP-16,VePe-sid)

  • Other useful drugs/modalities:

• Prostatic cancer:

  • Primary drugs:

    • Estrogens

    • GnRH agonist plus flutamide (Eulexin)

  • Other useful drugs/modalities:

• Wilms' tumor:

  • Primary drugs:

    • vincristine (Oncovin) plus dactinomycin (Cosmegen) (after surgery and radiation treatment)

  • Other useful drugs/modalities:

    • methotrexate

    • cyclophosphamide (Cytoxan)

    • doxorubicin (Adriamycin)

• Neuroblastoma:

  • Primary drugs:

    • cyclophosphamide (Cytoxan) plus doxorubicin (Adriamycin) plus vincristine (Oncovin)

  • Other useful drugs/modalities:

    • dactinomycin (Cosmegen)

    • daunorubicin (DaunoXome)

    • cisplatin (Platinol)

• Thyroid cancer:

  • Primary drugs:

    • radioiodine (I¹³¹)

    • doxorubicin (Adriamycin)

    • cisplatin (Platinol)

  • Other useful drugs/modalities:

    • bleomycin (Blenoxane)

    • flurouracil (5-FU)

    • melphalan (Alkeran)

• Adrenal carcinoma:

  • Primary drug:

    •  mitotane (Lysodren)

  • Other useful drugs/modalities:

    • suramin (investigational, 1998)

• Stomach or pancreatic carcinoma:

  • Primary drugs:

    • flurouracil (5-FU) plus doxorubicin (Adriamycin), mitomycin (Mutamycin)

  • Other useful drugs/modalities:

    • hydroxyurea (Hydrea)

    • lomustine (CCNU,CeeNU)

    • cisplatin (Platinol)

• Colon cancer:

  • Primary drugs:

    • flurouracil (5-FU) plus leucovorin or interferon (or both)

  • Other useful drugs/modalities:

    • cyclophosphamide (Cytoxan)

    • mitomycin (Mutamycin)

    • nitrosoureas

• Carcinoid:

  • Primary drugs:

    • doxorubicin (Adriamycin) + cyclophosphamide (Cytoxan)

    • fluorouracil (5-FU)

    • octreotide

  • Other useful drugs/modalities:

    • interferon

    • dactinomycin (Cosmegen)

    • streptozocin (Zanosar)

    •  methysergide (Sansert) (supportive therapy)

• Insulinoma:

  • Primary drugs:

    • streptozocin (Zanosar)

    • interferon

  • Other useful drugs/modalities:

    • doxorubicin (Adriamycin)

    • fluorouracil (5-FU)

    • mitomycin (Mutamycin)

    • streptozocin (Zanosar)

• Osteogenic sarcoma:

  • Primary drugs:

    • doxorubicin (Adriamycin)

    • methotrexate with citrovorum rescue after surgery

  • Other useful drugs/modalities:

    • cyclophosphamide (Cytoxan)

    • dacarbazine (DTIC)

    • interferon

    • ifofamide (Ifex)

• Melanoma:

  • Primary drugs:

    • dacarbazine (DTIC)

    • cisplatin (Platinol)

  • Other useful drugs/modalities:

    • lomustine (CCNU,CeeNU)

    • hydroxyurea (Hydrea)

    • mitomycin (Mutamycin)

    • dactinomycin (Cosmegen)

    • interferon

    • tamoxifen (Nolvadex)

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Salmon, S. E. and Sartorelli, A. C. Cancer Chemotherapy, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 903-904 (adapted from table 55-7)