Clinical Cases in Pharmacology Clinical Cases  ·  Cardiovascular  ·  Arrhythmias  ·  Complete Heart Block, Found Incidentally: Permanent Pacing or a Reversible Cause First
Cardiovascular Vol. I, Case 0172 — Arrhythmias

Complete Heart Block, Found Incidentally: Permanent Pacing or a Reversible Cause First

A single patient with a device-grade diagnosis found on a form meant to clear him for a new job, and a detail in his history that raises a real question of whether the block itself might not be permanent. The disagreement is about whether to test that possibility before committing him to a lifetime device.

Abbreviations, terms, and other agents mentioned in this case AV — atrioventricular  ·  IV — intravenous  ·  ECG — electrocardiogram  ·  escape rhythm — a backup pacemaker below the block; narrow-complex junctional escapes are faster and more reliable than wide-complex ventricular ones
Presentation

N.P., a 34-year-old man, works as a landscaper and spends most of his summer in yards and wooded lots across the region. About three weeks ago he had a few days of fever, fatigue, and a rash he assumed was an ordinary bug bite reaction and never had looked at. He came in this week only because a new employer required a pre-employment physical, and the ECG performed as part of that routine screening showed complete heart block — no electrical connection at all between his atria and ventricles, his ventricles sustained only by a slow but narrow-complex junctional escape. He has no symptoms: no syncope, no dizziness, no exertional limitation he's noticed.

Complete heart block is, on its own, a definite indication for a pacemaker, symptoms or not, given the real risk of syncope or sudden death from an unreliable escape rhythm. But his history — outdoor work, a fever-and-rash illness several weeks earlier that he never sought care for — raises a real, testable alternative: Lyme carditis, which can produce exactly this degree of AV block and, unusually among causes of complete heart block, can fully resolve with antibiotic treatment within days to weeks. It is not the only reversible cause — drug toxicity, hyperkalemia, acute ischemia, and post-operative block all resolve too — but it is the one his history actually points to. A 34-year-old committed to a permanent device carries that device, and its lifetime of lead revisions and generator changes, for a very long time if the underlying cause never actually needed one. He remains entirely asymptomatic on continuous monitoring, with a stable escape rhythm holding his heart rate in a survivable range while the team works out which path actually serves him.

N.P. · 34 Incidental finding, pre-employment ECG
History
Outdoor occupation; fever, fatigue, and an unevaluated rash ~3 weeks ago
Presentation
Complete AV block found incidentally, asymptomatic
ECG
No AV conduction; narrow-complex junctional escape, rate 42
Serologies
Lyme antibody testing sent, pending
Cardiac function
LVEF 58%, no structural abnormality on echocardiogram
Renal function
eGFR 108

A device-grade finding with a testable alternative

Electrophysiologist Opening

Complete heart block is a definite pacing indication on its own, and I don't think a possible reversible cause changes that enough to skip the device entirely. Even if Lyme carditis is confirmed and treated, resolution isn't guaranteed or immediate, and I'm not comfortable leaving a 34-year-old with no reliable AV conduction unprotected while we wait to find out.

Cardiologist Response

I'm not proposing we leave him unprotected — I'm proposing we don't commit him to a permanent device before we've genuinely tested whether this needs one at all. His exposure history and untreated illness fit Lyme carditis closely, and it's one of the few causes of complete heart block that resolves outright with treatment rather than merely improving. A 34-year-old carries a permanent pacemaker for potentially fifty years of lead revisions and generator changes — that's worth a real attempt to rule out a reversible cause first, provided we protect him properly while we do.

"Provided we protect him properly" is doing real work in that sentence, and I agree it has to mean more than a promise — it means a temporary pacing solution while treatment is underway, not an outpatient antibiotic course and a wait-and-see ECG in a month.

Clinical Pharmacologist Final

That's the actual plan that resolves both concerns: temporary pacing now, for genuine protection while his rhythm is unreliable, alongside intravenous ceftriaxone, 2 g once daily, for presumptive Lyme carditis given his exposure history and illness pattern, without waiting for serologies to result before starting treatment; once his conduction recovers he steps down to oral doxycycline to finish a two-to-three-week course. If his AV conduction recovers over the following one to two weeks, as it does in a real share of Lyme-associated complete heart block, the temporary system comes out and no permanent device is needed. If it doesn't recover, the permanent pacemaker conversation resumes from a position of actually having tried, not skipped, the reversible explanation.

Regimen selected
Ceftriaxone (IV)
Antibiotic · 2 g IV once daily, presumptive pending serologies
Started empirically for presumptive Lyme carditis given his exposure history and untreated illness, without waiting for confirmatory serology to result. Stepped down to oral doxycycline once AV conduction recovers, for a total course of 14–21 days.
Where this was left

Temporary pacing placed for protection; intravenous ceftriaxone started presumptively for Lyme carditis rather than waiting on serologies. Permanent pacemaker decision explicitly deferred, with a one-to-two-week reassessment of his intrinsic AV conduction planned before revisiting it.

If AV conduction recovers

Temporary system removed, no permanent device needed.

If conduction doesn't recover

Permanent pacemaker proceeds, informed by having genuinely tried the reversible explanation first.

Educational content only — a composite teaching case, not a real patient encounter or a substitute for clinical guidance. About These Cases →