Clinical Cases  ·  Allergy and Immunology Vol. I  ·  Head & Neck
← Back to Allergy and Immunology Vol. I
Allergy and Immunology

Head & Neck

17 cases on guideline-threshold combination therapy in allergic rhinitis, local and nonallergic rhinitis phenotypes, rhinitis medicamentosa, rhinitis in pregnancy, the unified-airway model, montelukast’s boxed warning, biologic-versus-revision-surgery thresholds in CRSwNP, macrolide therapy in chronic rhinosinusitis, allergic fungal sinusitis, AERD, acute rhinosinusitis against an untreated allergic baseline, senile rhinitis and anticholinergic burden, pediatric growth-suppression risk, allergic conjunctivitis, vernal keratoconjunctivitis, and SCIT-versus-SLIT immunotherapy selection — choose a case below to open its full multi-voice debate.

Allergy and ImmunologyHead & Neck
Moderate-Severe Allergic Rhinitis: A Congestion-Dominant Phenotype Against a Combination-Therapy Guideline

A congestion-dominant allergic rhinitis case tests whether a guideline severity threshold or an uncorrected nasal-spray technique error should drive the next therapeutic step.

Case 0001
Allergy and ImmunologyHead & Neck
Local Allergic Rhinitis: Treating a Positive Nasal Challenge When Every Systemic Test Is Negative

Six years of nasal symptoms, a negative systemic allergy workup, and a positive nasal allergen challenge raise whether immunotherapy is defensible without systemic IgE evidence.

Case 0002
Allergy and ImmunologyHead & Neck
Gustatory Rhinitis: Skipping the Standard Antihistamine Trial for a Reflex a Chef Can Reproduce on Demand

A chef's reproducible, food-triggered rhinorrhea raises whether a mechanistically clear nonallergic phenotype justifies skipping the usual antihistamine/steroid trial.

Case 0003
Allergy and ImmunologyHead & Neck
Rhinitis Medicamentosa Before an Audition: Abrupt Cessation With a Steroid Burst, or a Topical Bridge

A musician's oxymetazoline-induced rebound congestion tests whether an oral steroid burst or a trial-backed topical bridge is the better route to functional recovery before a deadline.

Case 0004
Allergy and ImmunologyHead & Neck
Rhinitis in Pregnancy: Does a Closed Organogenesis Window Reopen the Decongestant Question

A second-trimester patient's request for pseudoephedrine tests whether a gastroschisis signal tied to first-trimester exposure still applies once that window has closed.

Case 0005
Allergy and ImmunologyHead & Neck
One Airway, One Disease: When Does Treating the Nose Actually Move the Asthma

Two asthma patients with untreated allergic rhinitis test whether the unified-airway model changes management only when asthma control has already stalled.

Case 0006
Allergy and ImmunologyHead & Neck
Montelukast After the Boxed Warning: When a Nasal Spray Is Genuinely Not an Option

A child's sensory aversion to nasal sprays makes montelukast the only convenient option left, testing how the 2020 boxed warning should weigh against a genuine access barrier.

Case 0007
Allergy and ImmunologyHead & Neck
Recurrent Nasal Polyps After One Surgery: A Biologic Trial or a Second Trip to the Operating Room

Recurrent nasal polyps after prior sinus surgery raise whether a biologic matching the patient's trial-population profile should be tried before a second operation.

Case 0008
Allergy and ImmunologyHead & Neck
Low-Dose Macrolide Therapy in CRS: A Negative Large Trial Against a Positive Subgroup Signal

A negative randomized macrolide trial in chronic rhinosinusitis sits against an earlier trial's low-IgE subgroup signal, testing whether that phenotype changes the calculus.

Case 0009
Allergy and ImmunologyHead & Neck
Allergic Fungal Sinusitis: An Antigen-Load Argument Without a Trial to Match It

Recurrence risk in allergic fungal sinusitis raises whether oral itraconazole's case-series evidence justifies real toxicity monitoring alongside a trial-supported steroid taper.

Case 0010
Allergy and ImmunologyHead & Neck
AERD, Two Ways: When a Cardiac Indication for Aspirin Changes the Calculus

Two AERD patients with the same disease diverge on treatment once one already needs daily aspirin for his heart and the other has no reason to accept its risks.

Case 0011
Allergy and ImmunologyHead & Neck
Twelve Days of Sinus Symptoms and a “Double Worsening” Pattern Against an Untreated Allergic Baseline

A double-worsening symptom pattern meets IDSA's own criteria for bacterial sinusitis, but an entirely untreated allergic baseline complicates what the trial evidence actually supports.

Case 0012
Allergy and ImmunologyHead & Neck
Senile Rhinitis in a Patient Already Carrying an Anticholinergic Burden Score

An 83-year-old's idiopathic rhinorrhea responds mechanistically to a topical anticholinergic, testing whether it meaningfully adds to a burden score built around systemic drugs.

Case 0013
Allergy and ImmunologyHead & Neck
A Parent's Growth-Suppression Worry and a Real Agent-to-Agent Difference Behind It

A parent's internet-driven growth concern about a child's daily nasal steroid turns out to track a real, agent-specific difference in the pediatric growth-velocity literature.

Case 0014
Allergy and ImmunologyHead & Neck
Escalating Allergic Conjunctivitis to a Topical Steroid: How Soft Is Soft Enough

Severe seasonal allergic conjunctivitis inadequately controlled on a topical antihistamine raises how much caution a genuinely lower-risk soft steroid still deserves.

Case 0015
Allergy and ImmunologyHead & Neck
Vernal Keratoconjunctivitis's Fourth Consecutive Spring: Cumulative Steroid Exposure in a Growing Child

A fourth consecutive spring of vernal keratoconjunctivitis raises whether a steroid-sparing calcineurin inhibitor should replace another corticosteroid course in a growing child.

Case 0016
Allergy and ImmunologyHead & Neck
Choosing Between SCIT and SLIT: Trial Efficacy Against Real-World Adherence

A patient ready to escalate beyond pharmacotherapy weighs SCIT's broader trial evidence and office-visit burden against SLIT's convenience and documented lower real-world persistence.

Case 0017
← Back to Allergy and Immunology Vol. I