- Anthracyclines: Doxorubicin and
Daunorubicin
- IV administration; hepatic
metabolism; biliary excretion; some
urinary excretion; enterohepatic recirculation.
- Among the most useful
anticancer antibiotics
- Mechanism of action:
- DNA
intercalation -- blocking
synthesis of DNA and RNA; DNA
strands scission -- by affecting
topoisomerase II
- Altering
membrane fluidity and ion
transport
- Semiquinone
free radical an oxygen radical
generation (may be responsible
for myocardial damage)
- Clinical Uses:
- Doxorubicin -- very
important anticancer agent --
Carcinomas-Doxorubicin
| breast
carcinoma |
ovarian
carcinoma |
thyroid
carcinoma |
| endometrial
carcinoma |
testicular
carcinoma |
lung
carcinoma |
Sarcomas-Doxorubicin
| Ewing's sarcoma |
osteosarcoma |
rhabdomyosarcomas |
Hematologic Cancers-Doxorubicin
| acute
leukemia |
multiple
myeloma |
Hodgkin's
disease |
non-Hodgkin's
lymphoma |
- Adjuvant therapy in: osteogenic
sarcoma and breast cancer
|
