Hypothalamic and Pituitary Hormones
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Endocrine: Hypothalamic and Pituitary Hormones
Learning Objectives:The medical student should know and be able to discuss:
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Hormones of the Anterior Pituitary Gland
Hypothalamic |
Pituitary |
Target Organ |
Target Organ Hormone |
GHRH (+) |
GH (+) |
Liver |
Somatomedins |
CRH (+) |
ACTH (+) |
Adrenal Cortex |
glucocorticoids |
TRH (+) |
TSH (+) |
Thyroid |
T3 |
GnRH/LHRH (+) |
FSH (+) |
Gonads |
estrogen |
Dopamine (-) |
Prolactin (+) |
Lymphocytes |
Lymphokines |
(+), stimulant; (-), inhibitor
Table adapted from Fitzgerald, P.A. and Klonoff, D.C., Section VII. Endocring Drugs: Hypothalamic & Pituitary Hormones in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, p. 604. |
Hormone Systems and Clinical Pharmacology
GHRH (Growth Hormone-Releasing Hormone, a.k.a sermorelin)
pharmacodynamics, uses and adverse effects agents related to the GHRH system
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CRH (Corticotropin-Releasing Hormone)
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TRH (Thyroid-Releasing Hormone; protirelin)
GnRH (Gonadotropin-Releasing Hormone
LHRH, Luteinizing Hormone-Releasing Hormone)
NOTE: Human chorionic gonadotropin has no known effects on appetite, or on mobilization or distribution of body fat, contrary to some beliefs
Dopamine (PIF, Prolactin Inhibitory Factor)
Hormones of the Posterior Pituitary Gland