- "Action of corticotrophin-releasing
hormone (CRH) on cells of the adrenal cortex. CRH
binds to membrane receptors (R), which are
coupled to adenylate cyclase (AC) by stimulatory
G proteins (Gs). Adenylate cyclase is stimulated
and cAMP rises in the cell. cAMP activates
protein kinase A (PKA), which then phosphorylates
proteins (P-Proteins) involved in stimulating
ACTH secretion and the expression of the POMC
(proopiomelanocortin) gene. The proteolytic
processing of POMC occurs in the secretory
granulas where it is split into several hormones,
ACTH (adrenocorticotrophic hormone) and Beta-LPH
(Beta-lipotropin). "
- http://bio.bio.rpi.edu/Parsons/Universal%20Files/Lectures/L28Endocr/28cLect.html
- courtesy of Robert H.
Parsons, Ph.D., Rensselaer Polytechnic Institute,
used with permission
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