Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Stimulant laxatives:
1. Direct stimulation of the enteric nervous system
2. Stimulation of fluid secretion
3. Both
Extended use of stimulant laxatives (cathartics):
1. Possible adverse effect (destruction) of mesenteric plexus.
2. Possible cause of colonic atony.
3. Possible cause of colonic dilation.
4. A & B
5. B & C
6. A & C
7. A, B & C
Long-term use of stimulant laxatives may be safe in most patients.
1. True
2. False
Stimulant laxatives:
1. Likely induce a degree of low-grade small and large bowel inflammation..
2. Directly affects G.I. smooth muscle.
3. Both
4. Neither
Bisacodyl
1. Diphenylmethane derivative stimulant laxative.
2. Available as regular tablets and as enteric-coated tablets
3. Extended use (more than 10 consecutive days) may result in development of atonic, nonfunctional colon.
4. A & B
5. B & C
6. A & C
7. A, B & C
Bisacodyl excretion and metabolism:
1. Bisacodyl mainly excreted in the stool..
2. About 5% of the agent is absorbed.
3. Absorbed bisacodyl is ultimately excreted in the urine as the glucuronide (phase II metabolism)
4. A & B
5. B & C
6. A & C
7. A, B & C
Bisacodyl overdosage effect: fluid and electrolyte deficiency
1. True
2. False
Bisacodyl overdose effect: possible colonic ischemia
1. True
2. False
Bisacodyl use(s):
1. In combination with polyethylene glycol solutions for colonic cleansing in advance of colonoscopy.
2. Management of acute constipation
3. Both
4. Neither
Bisacodyl: may be safe for acute as well as long-term use
1. True
2. False

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions