Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Prucalopride (Resolor):
1. 5-HT4 receptor agonist (activator)
2. Possibly useful for managing chronic constipation.
3. Both
4. Neither
Misoprostol (Cytotec):
1. Prostaglandin analogue (synthetic) mainly used for protecting against and NSAID-induced gastric ulcers.
2. Not appropriate for use in womenwho may become pregnant as the drug induces labor.
3. As a "gastroprotectant" misoprostol can cause diarrhea (prostaglandin and related analogues induce colonic contractions.
4. A & B
5. B & C
6. A & C
7. A, B & C
This/these agents may be useful in treating constipation by influencing chloride (Cl^-)secretion.
1. Lubiprostone (Amatiza)
2. Linaclotide (Linzess and others)
3. Plecanatide (Trulance)
4. A & B
5. B & C
6. A & C
7. A, B & C
Lubiprostone:
1. Activator of Cl^- channels (prostanoid agent)
2. Activates adenylyl cyclase which enhances apical Cl^- conductance.
3. Both
4. Neither
Lubiprostone:
1. Enhances stool consistency
2. Increases frequency by improving motility.
3. Both
4. Neither
Lubiprostone:
1. Significant bioavailability
2. Helpful in managing opioid-induced constipation.
3. Useful in treating chronic constipation.
4. A & B
5. B & C
6. A & C
7. A, B & C
Linaclotide:
1. Promote cyclic GMP synthesis.
2. Increased cyclic GMP levels promote increased Cl^- and bicarbonate secretion into the intestinal lumen.
3. Both
4. Neither
Linaclotide clinical use(s):
1. Helpful in treating irritable bowel syndrome (IBS) which presents mainly as constipation.
2. Useful in treating chronic adult constipation.
3. Both
4. Neither
Side effect(s) associated with linaclotide administration:
1. Abdominal pain
2. Diarrhea
3. Headache
4. A & B
5. B & C
6. A & C
7. A, B & C
Plecanatide acts by virtually the same mechanism as linaclotide.
1. True
2. False

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions