Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
Dopamine receptor antagonists exert their antinauseant and antiemetic action
at D2 receptors localized in the chemoreceptor trigger zone (CTZ).
True
False
The effect of D2 receptor blockade at the CTZ that results in anti-nausea and antiemetic action is reduction of excitatory neurotransmitter synaptic release.
True
False
Among the phenothiazine-class of antinauseants, this/these drug(s) represent the most commonly used "general-purpose" agents in both children and adults.
Chlorpromazine
Prochlorperazine
Both
Neither
Concerning the use of prochlorperazine (or chlorpromazine):
These agents may not always be effective in managing cancer chemotherapy-cause emesis.
These agents exhibit anticholinergic and anti-histaminic activities helpful in suppressing nausea and vomiting due to motion sickness or those of gastrointestinal origin.
Both
Neither
Primary adverse action(s) associated with phenothiazines employed as antinauseant sin antiemetics include/includes:
Dystonia and other extrapyramidal neurological effects.
Hypotension
Both
Neither
Phenothiazine administration are contraindicated in elderly patients exhibiting dementia-related psychosis due to attendant increases in mortality.
True
False
Olanzapine:
Classified as an "atypical" antipsychotic drug.
Characterized as an antagonist at dopamine (D1-4) receptors.
Characterized as a 5-HT2 receptor blocker.
A & B
B & C
A & C
A, B & C
Olanzapine (Zyprexa):
Effective in preventing chemotherapy induced delayed nausea and vomiting
Treatment of refractory non-chemotherapy-induced nausea and vomiting.
Both
Neither
Olanzapine administration may result in a variety of side effects including those affecting the central nervous system, cardiovascular system and metabolism.
True
False
Metoclopramide (Reglan) appears useful and management of delayed emesis.
