Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Emetogenic chemotherapy is associated with both an acute phase and a delayed phase. Agents belonging to this class of drugs are particularly effective for managing the acute phase.
1. 5-HT₃ receptor blockers
2. Neurokinin 1 (NK1)
Emetogenic chemotherapy is associated with both an acute phase and a delayed phase. Agents belonging to this class of drugs are particularly effective for managing the delayed phase.
1. Neurokinin receptor blockers (NK₁ receptor antagonist)
2. 5-HT₃ receptor antagonists
NK₁ receptors represent receptors for the neuropeptide substance P.
1. True
2. False
Example(s) of (an) NK₁ receptor antagonist(s):
1. Aprepitant (Emend)
2. Rolapitant (Varubi; Varuby)
3. Both
4. Neither
Rolapitant exhibits an unusually long t_1/2(about four days).
1. True
2. Falls
Administration, plasma protein binding and metabolism of aprepitant:
1. Aprepitant is typically given as monotherapy to manage delayed emesis.
2. Aprepitant is substantially associated with plasma protein to >95%.
3. Aprepitant is metabolized by the liver drug metabolizing system, the cytochrome P450 system mainly catalyzed by the CYP3A4 isoform.
4. A & B
5. B & C
6. A & C
7. A, B & C
Due to the possibility of life-threatening ECG QT prolongation, aprepitant should not be administered to patients receiving:
1. Cisapride (Propulsid)
2. Pimozide (Orap)
3. Both
4. Neither
Example(s) of drug(s) metabolized by CYP3A4 and thus subject to dose adjustment in individuals receiving aprepitant (CYP3A4 substrate)
1. Methylprednisolone
2. Warfarin
3. Dexamethasone
4. A & B
5. B & C
6. A & C
7. A, B & C
Rolapitant:
1. Administered typically in a single-dose, 1-2 hours before chemotherapy (in combination with dexamethasone and a 5-HT₃ antagonist)
2. Administration of rolapitant may be associated with adverse effects including neutropenia, dizziness, reduced appetite.
3. Both
4. Neither
A relatively recent approved drug combination involves netupitant along with palonosetron.
1. True
2. False

Medical Pharmacology: Gastrointestinal Pharmacology Practice Questions