Medical Pharmacology Chapter 3: Pharmacodynamics Practice Questions

Aspirin poisoning: an important cause of morbidity and mortality in overdose setting.
1. True
2. False
Characteristic(s) of aspirin overdose:
1. Pyloric valve spasm
2. Enteric forms of aspirin may form bezoars.
3. Both
4. Neither
Following drug overdose, timeframe that is typical for emergency medical observation.
1. 1-2 hours
2. 4-6 hours
3. 8-12 hours
4. 24-36 hours
Which one(s) of the following exhibit initial overdose symptoms at a time greater than the typical 4-6 hours following ingestion?
1. Monoamine oxidase inhibitors
2. Valproic acid
3. Warfarin-like anticoagulant drugs
4. A & B
5. B & C
6. A, B & C
Concerning valproic acid in the overdose setting:
1. Valproic acid and overdose may cause coma.
2. In overdose settings, first-order metabolic transformation becomes saturated, resulting in at least a doubling of the elimination half-time.
3. Both
4. Neither
Side effects can be considered equivalent to toxic effects.
1. True
2. False
Classification(s) of drug toxicity:
1. Pharmacological
2. Genotoxic
3. Pathological
4. A & B
5. B & C
6. A & C
7. A, B & C
An example of pathological toxicity:
1. Barbiturate induced CNS depression
2. Acetaminophen metabolite due to the action of the cytochrome p450 isoforms CYP2E1.
3. Ionizing radiation
Categories of allergic reactions:
1. Anaphylactic reactions
2. Cytolytic reactions
3. Arthrus reactions
4. Delayed hypersensitivity reactions
5. A & B
6. A, B & C
7. All of the answers are correct i.e. A, B, C & D
Example(s) of (an) idiosyncratic drug reaction(s):
1. Unusually high insensitivity to high drug doses
2. Usually high sensitivity to low drug doses
3. Both
4. Neither