Medical Pharmacology: Pharmacokinetic Practice Questions
Choose the correct answer for each question.
Primary mechanism allowing drug movement across biological membranes.
Active transport
Facilitated diffusion
Passive diffusion
An example of a lipid raft in a biological membrane would be a region associated with sphingolipids and cholesterol.
True
False
Passive transport:
Drug enters the membrane by diffusion.
Penetration of the drug is described by its concentration gradient across the membrane and its lipid solubility.
Both
Neither
Under steady-state (equilibrium) conditions, the concentration of unbound drug is defined as the same on both sides of the membrane (assuming the drug is nonelectrolyte)
True
False
The "standard" drug dose:
Based on trials in healthy individuals and patients.
These individuals exhibit "average" ability to absorb, distribute the drug, and eliminate the drug.
Both
Neither
Concerning Volume of Distribution:
Volume of distribution describes the ratio between the amount of drug in the body and the concentration of drug in plasma or blood.
The volume of distribution is an apparent volume in that volumes can exceed the physical volume in the body.
Both
Neither
Drug clearance is the ratio of the drug's rate of elimination divided by the drug concentration
True
False
Clearance, similar to volume of distribution, may be calculated relative to blood (CCLb), plasma (CLp) or unbound in water (CLu).
True
False
Some drugs, such as ethanol or phenytoin exhibit capacity-limited elimination, in which clearance varies depending on drug concentration.
True
False
Capacity-limited elimination:
Saturable
Concentration-dependent clearance
Both
Neither
Clearance cannot be usefully defined for agents with capacity-limited elimination due to clearance variation with concentration; therefore, area-under-the-curve (AUC) cannot be used appropriately for clearance calculation of these drugs.
If
you wish to return to the Table of Contents in ENGLISH, press
the RETURN button above.
Otherwise, if the text is NOT displayed in English and
you are ready to leave this page,
Press here
to return to the Table of Contents
Source Material:
Buxton ILO Chapter
2: Pharmcokinetics: The Dynamics of Drug Absorption,
Distribution, Metabolism, and Elimiation in Goodman & Gilman's: The Pharmacological
Basis of Therapeutics, 14e, (Brunton LL H Knollmann
BC, eds) McGraw-Hill Education, 2023.
Holford NHG Chapter
3: Pharmacokinetics & Pharmacodynamics: Rational Dosing &
the Time Course of Drug Action:
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Baca QJ Golan DE
Pharmacokinetics Chapter 3:
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy.
(Golan DE, editor-in chief, Armstrong EJ Armstrong AW, associate
editors) 4e Wolters Kluwer 2017.
Flood P Shafer SL
Chapter 2 Basic Principles of Pharmacology in Stoelting's
Pharmacology & Physiology in Anesthetic Practice (Glood P
Rathmell JP Urman RD, eds) 6e Wolters Kluwer 2022.
Burchum JR Rosenthal
LD Lehne's Pharmacology for Nursing Care Unit II Chapter 4
Pharmcokinetics 11 e Elsevier 2022.
