Medical Pharmacology: Pharmacokinetic Practice Questions

Following drug absorption, drug distribution system/systems involve/involves:
1. Blood
2. Lymphatic vessels
3. Both
4. Neither
Limitations/limitations on a drugs ability to interact in its target site(s):
1. Metabolism that inactivates the drug, typically hepatic metabolism, limiting pharmacologically relevant drug concentrations from reaching target sites.
2. Excretion eliminates the drugthus reducing drug levels available for physiological action.
3. Both
4. Neither
Central pharmacokinetic compartment:
1. Body compartments which dilute the drug within one minute following injection
2. Such a central compartment element includes the venous blood volume of the arm.
3. Both
4. Neither
Body central compartment/compartments (drug dilution within the first minute following injection):
1. Heart
2. Lung
3. Both
4. Neither
Drugs which exhibit high lipid solubility may be rapidly taken up during first passage through the lung.
1. True
2. False
First-pass pulmonary uptake a dose of lidocaine, fentanyl, and propranolol:
1. <10%
2. About 50%
3. >65%
Tissues/Tissue described as the "vessel-rich group" and receive most of the arterial blood flow:
1. Brain
2. Heart
3. Liver
4. Kidney
5. A & B
6. B & C
7. A, B, C & D
Tissue drug concentration in the organs belonging to the "vessel-rich group", due to rapid blood flow, equilibrates quickly with arterial blood.
1. True
2. False
Higher capacity to absorb highly lipid-soluble drugs:
1. Highly perfused tissue
2. Fat
3. Both about the same
Redistribution of drug from highly perfused tissue to fat accounts for drug effect termination after administration of an IV anesthetic or fat-soluble agent such as fentanyl.
1. True
2. False