Medical Pharmacology: Pharmacokinetic Practice Questions

Capacity-limited drug elimination is also referred to as flow-dependent elimination.
1. True
2. False
Concerning flow-dependent elimination:
1. Drugs that exhibit flow -dependent elimination may be also referred to as "high-extraction" drugs
2. Drugs that are highly extracted from blood flow may be influenced by blood cell partitioning and plasma protein binding.
3. Both
4. Neither
Proteins as drugs:
1. Most proteins as drugs exhibit similar pharmacokinetics, exhibiting half-life of about two weeks.
2. Most of the effect of these drugs are caused by binding to the target site and elimination of the drug may depend on elimination of the target for example, T cells of the immune system.
3. Both
4. Neither
Simplest of drug routes of administration:
1. Parenteral
2. Enteral
3. Transdermal
4. Through mucous membranes
Factor/factors that may limit drugs utilizing the oral (enteral) route of administration:
1. Acidic stomach pH
2. Basic duodenum pH
3. Both
4. Neither
Concerning oral administered drugs:
1. Drug must be stable when traversing the G.I. tract epithelium.
2. Given the difficulty of drugtransport across intact epithelium, drugs usually cross cell membranes at both apical and basal surfaces prior to entering the blood.
3. Both
4. Neither
Neutral drugs or hydrophobic drugs usually cross cell membranes more readily than charged or hydrophilic drugs.
1. True
2. False
Orally administered drugs may be affected by hepatic, first-pass metabolism.
1. True
2. False
Drugs that utilize parenteral administration directly access the systemic circulation (or CSF or vascularized tissue).
1. True
2. False
A disadvantage that may be associated with parenteral drug administration is increased possibility of infection.
1. True
2. False