Medical Pharmacology: Pharmacokinetic Practice Questions

Drug binding to plasma albumin:
1. Highly selective
2. Drugs do not compete with endogenous substances at the same albumin binding sites.
3. Both
4. Neither
Drug such as sulfonamides can displays unconjugated bilirubin from albumin binding sites. This displacement elevates the risk of neonatal bilirubin encepalopathy.
1. True
2. False
Typically increases plasma protein concentration:
1. Age
2. Renal failure
3. Both
4. Neither
Associated with a decrease in plasma protein levels:
1. Hepatic disease
2. Pregnancy
3. Both
4. Neither
Actual free drug concentration that determines the extent of drug-receptor binding is highly sensitive to the degree of drug-plasma protein binding.
1. True
2. False
The most important plasma protein associated with drug binding:
1. Lipoprotein A
2. Erythrocyte membrane protein 4
3. Albumin
4. Alpha glycoprotein
Albumin levels in the bloodstream:
1. Albumin must be continually replenished because albumin readily passes through membrane pores in the capillary wall.
2. Albumin levels in the blood tend to decline because transport systems act to remove albumin from the blood.
3. Both
4. Neither
Binding between albumin and drugs is always considered reversible.
1. True
2. False
Lipid-soluble, nonionized drug may readily pass across the placenta.
1. True
2. False
Unlikely to pass across placental membranes: protein-bound drugs
1. True
2. False