Medical Pharmacology: Pharmacokinetic Practice Questions

Bioavailability: The unchanged drug fraction reaching systemic circulation.
1. True
2. False
Area under the blood concentration-time curve (AUC):
1. Proportional to the drug dose
2. Proportional to the extent of drug bioavailability if first-order elimination applies.
3. Both
4. Neither
If the drug is administered by the IV route of administration, the bioavailability is typically estimated as 0.5 or 50%.
1. True
2. False
Bioavailability of the drug administered by the rectal route of administration:
1. Estimated between 30% to less than 100%.
2. Bioavailability by this route of administration may be associated with reduced first-pass effect compared oral administration.
3. Both
4. Neither
Some drugs, following oral administration, may be incompletely absorbed (only about 70% of the digoxin dose is found in the systemic circulation). This reduced absorption results from "lack of absorption from the gut"
1. True
2. False
If the drug is too lipophilic, the drug may be insufficiently soluble to traverse the water layer near the cell.
1. True
2. False
If the drug is too hydrophilic, the drug will be unable to cross the lipid component of the cell membrane, hydrophobic component.
1. True
2. False
Some drugs may not be absorbed because they will be transported out of gut wall cells due to the presence of a reverse transporter (P-glycoprotein,P-gp).
1. True
2. False
Route of administration that tends to prolong drug absorption duration:
1. Oral
2. Topical
3. Transdermal
4. Sublingual
Route of administration that tends to avoid the first-pass effect:
1. Oral
2. Topical
3. Transdermal
4. Sublingual
Route of administration that tends to be most convenient:
1. Oral
2. Topical
3. Transdermal
4. Rectal or sublingual
Route of administration which tends to maximize side of action concentration while minimizing drug concentration at other sites:
1. Oral
2. Topical
3. Transdermal
4. Sublingual