Medical Pharmacology: Pharmacokinetic Practice Questions

Alterations in protein binding may incorrectly suggest a change in drug clearance, even if drug elimination is not changed.
1. True
2. False
Clearance and albumin plasma protein concentration:
1. Some drugs such as salicylates and disopyramide exhibits significant binding to plasma albumin.
2. Reduce plasma albumin levels may result in reduced total drug levels. In certain diseases, plasma albumin concentrations are reduced.
3. Both
4. Neither
α1-acid glycoprotein and drug clearance:
1. This glycoprotein avidly binds drugs such as quinidine, lidocaine, and propranolol. These agents are used in management of certain cardiovascular conditions.
2. Acute inflammatory diseases may induce increases in α1-acid glycoprotein which in turn alters total drug plasma concentration even given the drug elimination is unaltered.
3. Both
4. Neither
Some drugs exhibit significant binding to red blood cells.
1. True
2. False
Transdermal drug administration:
1. Some drugs are sufficiently lipophilic that passive diffusion through the skin represents an effective route of administration.
2. Transcutaneous drug absorption results in drug delivery directly to the blood
3. Both
4. Neither
Mucous membranes and drug administration: This route of administration is associated with:
1. Rapid absorption
2. Relatively convenient administration
3. Extensive first-pass metabolism
4. A & B
5. B & C
6. A, B & C
Using mucous membranes as a drug's route of administration:
1. Is associated with slow but steady drug entry into the systemic circulation since mucous membranes exhibit limited vascularity.
2. Because of the limited vascularity associated with mucous membranes, the onset of drug action is usually slow.
3. Both
4. Neither
Transdermal drug administration:
1. Often appropriate for drugs that need to be administered slowly, continuously, especially over long periods.
2. One disadvantage of transdermal drug delivery is an elevated risk of infection.
3. Both
4. Either
The major, probably primary, disadvantage of enteric-coded drug preparations is that drug absorption may be more variable, compared to standard tablets.
1. True
2. False
Rationale(s) for using enteric formulation of drugs:
1. Limiting gastric discomfort in the stomach due to the drug.
2. Limiting exposure of drugs to stomach acid and pepsin, agents that may result in drug degradation.
3. Both
4. Neither