Medical Pharmacology: Pharmacokinetic Practice Questions

Absorption: gaseous as well as volatile drugs
1. May occur through respiratory tract mucous membranes.
2. May occur through pulmonary epithelial cells.
3. Both
4. Neither
Characteristic/characteristics associated with pulmonary absorption:
1. Nearly immediate drug absorption into the blood
2. No hepatic first-pass effect.
3. Both
4. Neither
With pulmonary absorption, in treating certain pulmonary diseases, the drug is immediately directed to the desired site of action.
1. True
2. False
Inhaled nitric oxidemay be used in managing pulmonary hypertension in both infants and adults.
1. True
2. False
Factor/factors that may influence drug absorption following intramuscular injection:
1. Rate of blood flow at the site of injection.
2. Local heating
3. Exercise
4. A & B
5. B & C
6. A, B & C
Faster rate of drug absorption (drug is in aqueous solution):
1. Drug is injected into the gluteus maximus.
2. Drug is injected into the deltoid muscle.
3. Both are about equal
Intrathecal drug administration:
1. Drug entry across the blood-brain barrier may be limited by the activity of P-glycoprotein (MDR1) and other transporters that remove drugs from the central nervous system.
2. Drugs may be sometimes injected directly into the spinal subarachnoid space.
3. Drugs may be injected, for example in treating serious CNS infections, directly into the intraventricular cavity.
4. A & B
5. B & C
6. A & C
7. A, B & C
Drugs introduced by means of mucous membranes may be especially useful for immunotherapy.
1. True
2. False
Rectal administration:
1. About 50% of the drug introduced rectally will bypass hepatic first-pass metabolic effects.
2. Rectal absorption of drugs may be characterized as incomplete and irregular.
3. Both
4. Neither
Drug-eluting stents as well as drug delivery by microneedle patches may be useful in local drug delivery with limited systemic exposure.
1. True
2. False