Medical Pharmacology: Drug Metabolism Practice Questions
Choose the correct answer for each question.
Drug oxidation reactions:
Typically involve membrane-associated enzymes mainly associated with hepatocyte endoplasmic reticulum (smooth).
Most of these enzymes belong to the cytochrome P450 class and are heme protein monooxygenases.
Both
Neither
Cytochrome P450 enzymes are involved in the metabolism of:
About 20% of currently used drugs
About 50% of currently used drugs
About 75% of currently used drugs
Greater than 90% of currently used drugs
Description of cytochrome P450 mediated drug oxidation reaction: Drug + O2 + NADPH
→ Drug-OH +H20 + NADP+
True
False
Hepatic cytochrome P450 oxidases:
Narrow substrate specificity (acts on many different chemicals)
Cytochrome P450 enzymes (including enzyme isoforms (forms of cytochrome P450 enzymes with differing substrate specificities)) account for over 95% of oxidative drug metabolism.
Both
Neither
Alcohol is oxidized by a specific cytochrome P450 enzyme, converting alcohol to an aldehyde derivative.
True
False
Monoamine oxidase (MAO)
This enzyme oxidizes amine-containing chemicals such as catecholamines and tyramine.
Monoamine oxidase represents an important non-P450 enzyme that plays an important role in drug metabolism.
Both
Neither
Cytochrome P450:
Cytochrome P450 refers to a group of about 12 very similar enzyme families.
CYP1, CYP2, and CYP3 represent cytochrome P450 families associated with drug metabolism.
Both
Neither
Individual forms of cytochrome P450 families have their own designation, such as CYP1A2, CYP2D6, and CYP3A4, all prominent drug metabolism cytochrome P450 isoforms.
True
False
Therapeutically important consequence/consequences of drug metabolism:
Increased toxicity
Reduced toxicity
Prodrug activation
A & B
B & C
A, B & C
Therapeutically important consequence/consequences of drug metabolism:
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Source Material:
Buxton ILO Chapter
2: Pharmcokinetics: The Dynamics of Drug Absorption,
Distribution, Metabolism, and Elimiation in Goodman & Gilman's:
The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H
Knollmann BC, eds) McGraw-Hill Education, 2023.
Gonzalez FJ
Coughtrie M Chapter 5: Drug Metabolism in Goodman & Gilman's:
The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H
Knollmann BC, eds) McGraw-Hill Education, 2023.
Holford NHG Chapter
3: Pharmacokinetics & Pharmacodynamics: Rational Dosing &
the Time Course of Drug Action: in Basic & Clinical
Pharmacology (Katzung BG, Editor; Vanderah TW, Associate
editor) 15e McGraw Hill 2021.
Correia MA Chapter 4
Drug Biotransformation in Basic &
Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate
editor) 15e McGraw Hill 2021.
Baca QJ Golan DE
Pharmacokinetics Chapter 3: Principles of Pharmacology:
The Pathophysiologic Basis of Drug Therapy. (Golan DE, editor-in
chief, Armstrong EJ Armstrong AW, associate editors) 4e Wolters
Kluwer 2017.
Guengerich FP
Chapter 4: Drug Metabolism in
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE, editor-in
chief, Armstrong EJ Armstrong AW, associate editors) 4e Wolters
Kluwer 2017.
Flood P Shafer SL
Chapter 2 Basic Principles of Pharmacology in Stoelting's
Pharmacology & Physiology in Anesthetic Practice (Glood P
Rathmell JP Urman RD, eds) 6e Wolters Kluwer 2022.
Burchum JR Rosenthal
LD Lehne's Pharmacology for Nursing Care Unit II Chapter 4
Pharmcokinetics 11 e Elsevier 2022.
